Department of Microbiology and Molecular Genetics, School of Medicine, University of California, Irvine, Irvine, CA, USA.
Department of Molecular Biology and Biochemistry, School of Biological Sciences, University of California, Irvine, Irvine, CA, USA; Chao Family Comprehensive Cancer Center, University of California, Irvine, Irvine, CA, USA.
Mol Cell. 2024 Jun 6;84(11):2011-2013. doi: 10.1016/j.molcel.2024.05.013.
In this issue of Molecular Cell, Yi et al. demonstrate that reduced mTORC1 activity induces the CTLH E3 ligase-dependent degradation of HMGCS1, an enzyme in the mevalonate pathway, thus revealing a unique connection between mTORC1 signaling and the degradation of a specific metabolic enzyme via the ubiquitin-proteasome system.
在本期《分子细胞》中，易等人证明，mTORC1 活性的降低会诱导 CTLH E3 连接酶依赖性降解 HMGCS1，后者是甲羟戊酸途径中的一种酶，从而揭示了 mTORC1 信号与通过泛素-蛋白酶体系统降解特定代谢酶之间的独特联系。
