Ultrasound Department, The Second Affiliated Hospital of Xi'an Jiaotong University, Xi'an 710004, China.
School of Automation, Xi'an University of Posts and Telecommunications, Xi'an 710121, China.
Biochem Pharmacol. 2024 Aug;226:116341. doi: 10.1016/j.bcp.2024.116341. Epub 2024 Jun 5.
Maximizing treatment efficacy and forecasting patient prognosis in cancer necessitates the strategic use of targeted therapy, coupled with the prompt precise detection of malignant tumors. Theutilizationof gaseous systems as an adaptable platform for creating nanobubbles (NBs) has garnered significant attention as theranostics, which involve combining contrast chemicals typically used for imaging with pharmaceuticals to diagnose and treattumorssynergistically in apersonalizedmanner for each patient. This review specifically examines the utilization of oxygen NBsplatforms as a theranostic weapon in the field of oncology. We thoroughly examine the key factors that impact the effectiveness of NBs preparations and the consequences of these treatment methods. This review extensively examines recent advancements in composition schemes, advanced developments in pre-clinical phases, and other groundbreaking inventions in the area of NBs. Moreover, this review offers a thorough examination of the optimistic future possibilities, addressing prospective methods for improvement and incorporation into widely accepted therapeutic practices. As we explore the ever-changing field of cancer theranostics, the incorporation of oxygen NBs appears as a promising development, providing new opportunities for precision medicine and marking a revolutionary age in cancer research and therapy.
为了最大限度地提高癌症治疗效果和预测患者预后,需要战略性地使用靶向治疗,并及时准确地检测恶性肿瘤。气体系统作为一种可适应的平台,用于制造纳米气泡(NBs),在治疗学方面引起了广泛关注,它将通常用于成像的对比化学物质与药物结合起来,以协同的方式对肿瘤进行诊断和治疗,从而为每位患者提供个性化的治疗。本综述专门研究了氧 NB 平台作为肿瘤学领域治疗学武器的应用。我们深入研究了影响 NBs 制备效果的关键因素以及这些治疗方法的后果。本综述广泛考察了组成方案的最新进展、临床前阶段的先进发展以及 NBs 领域的其他开创性发明。此外,本综述全面探讨了乐观的未来可能性,提出了改进和纳入广泛接受的治疗实践的预期方法。随着我们探索癌症治疗学不断变化的领域,氧 NBs 的应用似乎是一个很有前途的发展方向,为精准医学提供了新的机会,标志着癌症研究和治疗的一个革命性时代的到来。