Western University, Schulich School of Medicine and Dentistry, London Health Sciences Centre and St Joseph Health Care, Department of Anesthesia and Perioperative Medicine, London, Ontario, Canada.
Western University, Schulich School of Medicine and Dentistry, London Health Sciences Centre and St Joseph Health Care, Department of Anesthesia and Perioperative Medicine, London, Ontario, Canada.
Braz J Anesthesiol. 2024 Jul-Aug;74(4):844524. doi: 10.1016/j.bjane.2024.844524. Epub 2024 Jun 5.
Prior research has established the effectiveness of magnesium in relieving postoperative pain. This article aims to evaluate magnesium sulfate for perioperative analgesia in adults undergoing general abdominal surgery under general anesthesia.
The primary aim was to assess pain scores at 6 and 24 hours postoperatively in patients receiving magnesium sulfate vs. the control group. Secondary outcomes were postoperative opioid consumption, perioperative complications, and time to rescue analgesia.
A comprehensive database search identified studies comparing magnesium sulfate with control in adults undergoing general anesthesia for general abdominal surgery. Using random-effects models, data were presented as mean ± Standard Deviation (SD) or Odds Ratios (OR) with corresponding 95% Confidence Intervals (95% CI). A two-sided p-value < 0.05 was considered statistically significant.
In total, 31 studies involving 1762 participants met the inclusion criteria. The magnesium group showed significantly lower postoperative pain scores at both early (within six hours) and late (up to 24 hours) time points compared to the control group. The early mean score was 3.1 ± 1.4 vs. 4.2 ± 2.3, and the late mean score was 2.3 ± 1.1 vs. 2.7 ± 1.5, resulting in an overall Mean Difference (MD) of -0.72; 95% CI -0.99, -0.44; p < 0.00001. The magnesium group was associated with lower rates of postoperative opioid consumption and shivering and had a longer time to first analgesia administration compared to the saline control group.
Magnesium sulfate administration was linked to reduced postoperative pain and opioid consumption following general abdominal surgery.
先前的研究已经证实了镁在缓解术后疼痛方面的有效性。本文旨在评估硫酸镁在全身麻醉下接受普通腹部手术的成年人围手术期镇痛中的作用。
主要目的是评估接受硫酸镁与对照组的患者在术后 6 小时和 24 小时的疼痛评分。次要结局是术后阿片类药物消耗、围手术期并发症和补救性镇痛时间。
全面数据库检索确定了比较硫酸镁与全身麻醉下接受普通腹部手术的成年人的对照组的研究。使用随机效应模型，数据以平均值±标准偏差（SD）或比值比（OR）及其相应的 95%置信区间（95%CI）呈现。双侧 p 值 < 0.05 被认为具有统计学意义。
共有 31 项研究纳入了 1762 名参与者，符合纳入标准。与对照组相比，镁组在早期（6 小时内）和晚期（24 小时内）时间点的术后疼痛评分明显较低。早期平均评分分别为 3.1 ± 1.4 与 4.2 ± 2.3，晚期平均评分分别为 2.3 ± 1.1 与 2.7 ± 1.5，总平均差异（MD）为-0.72；95%CI-0.99，-0.44；p < 0.00001。与生理盐水对照组相比，镁组术后阿片类药物消耗和寒战发生率较低，首次镇痛给药时间较长。
在普通腹部手术后，硫酸镁的应用与术后疼痛减轻和阿片类药物消耗减少有关。
