Department of Molecular Biology and Genetics, Aarhus University, Aarhus, Denmark.
Department of Molecular Biology and Genetics, Aarhus University, Aarhus, Denmark; The Danish Research Institute for Translational Neuroscience (DANDRITE), Denmark.
J Mol Biol. 2024 Nov 1;436(21):168645. doi: 10.1016/j.jmb.2024.168645. Epub 2024 Jun 5.
Biomolecular condensates are increasingly recognized as important drivers of cellular function; their dysregulation leads to pathology and disease. We discuss three questions in terms of the impending utility of data-driven techniques to predict condensate-driven biological outcomes, i.e., the impact of cellular state changes on condensates, the effect of condensates on biochemical processes within, and condensate properties that result in cellular dysregulation and disease.
生物分子凝聚物越来越被认为是细胞功能的重要驱动因素；它们的失调会导致病理和疾病。我们将根据数据驱动技术在预测凝聚物驱动的生物学结果方面的潜在应用，讨论三个问题，即细胞状态变化对凝聚物的影响、凝聚物对内部生化过程的影响，以及导致细胞失调和疾病的凝聚物特性。
