Pathology Post Graduate Program, Fluminense Federal University (UFF), Niterói, RJ, Brazil.
Pathology Post Graduate Program, Fluminense Federal University (UFF), Niterói, RJ, Brazil.
Life Sci. 2024 Aug 15;351:122793. doi: 10.1016/j.lfs.2024.122793. Epub 2024 Jun 6.
The enteric nervous system (ENS) regulates numerous functional and immunological attributes of the gastrointestinal tract. Alterations in ENS cell function have been linked to intestinal outcomes in various metabolic, intestinal, and neurological disorders. Chronic kidney disease (CKD) is associated with a challenging intestinal environment due to gut dysbiosis, which further affects patient quality of life. Although the gut-related repercussions of CKD have been thoroughly investigated, the involvement of the ENS in this puzzle remains unclear. ENS cell dysfunction, such as glial reactivity and alterations in cholinergic signaling in the small intestine and colon, in CKD are associated with a wide range of intestinal pathways and responses in affected patients. This review discusses how the ENS is affected in CKD and how it is involved in gut-related outcomes, including intestinal permeability, inflammation, oxidative stress, and dysmotility.
肠神经系统（ENS）调节胃肠道的许多功能和免疫属性。ENS 细胞功能的改变与各种代谢、肠道和神经紊乱中的肠道结局有关。由于肠道菌群失调，慢性肾脏病（CKD）与具有挑战性的肠道环境相关，这进一步影响了患者的生活质量。尽管 CKD 的肠道相关影响已被深入研究，但 ENS 在这一谜团中的参与仍不清楚。ENS 细胞功能障碍，如小肠道和结肠中的神经胶质反应和胆碱能信号转导的改变，与受影响患者的广泛肠道途径和反应有关。这篇综述讨论了 CKD 中 ENS 是如何受到影响的，以及它如何参与与肠道相关的结局，包括肠道通透性、炎症、氧化应激和运动障碍。
