肠道会是揭开帕金森病发病机制之谜的缺失一环吗？
Can the gut be the missing piece in uncovering PD pathogenesis?
机构信息
Inserm, U1235, Faculté de Médecine, 1 rue Gaston Veil, F-44035 Nantes, France; University Nantes, Faculté de Médecine, 1 rue Gaston Veil, F-44035 Nantes, France; CHU Nantes, Clinical Gerontology Department, Bd Jacques Monod, F-44093 Nantes, France.
Inserm, U1235, Faculté de Médecine, 1 rue Gaston Veil, F-44035 Nantes, France; University Nantes, Faculté de Médecine, 1 rue Gaston Veil, F-44035 Nantes, France; CHU Nantes, Clinical Gerontology Department, Bd Jacques Monod, F-44093 Nantes, France; CHU Nantes, Department of Clinical Neurophysiology, Bd Jacques Monod, F-44093 Nantes, France.
出版信息
Parkinsonism Relat Disord. 2019 Feb;59:26-31. doi: 10.1016/j.parkreldis.2018.11.014. Epub 2018 Nov 12.
It is now well established that Parkinson's disease (PD) is not only a movement disorder of the CNS but also a gastrointestinal disorder affecting the enteric nervous system (ENS). The gut-brain axis is a bidirectional communication between the brain and the gastrointestinal tract, which comprises besides the CNS and the ENS, the intestinal epithelial barrier, the intestinal microbiota and the enteroendocrine systems. In this review, we present the clinical and pathological evidence suggesting that the gut-brain axis is dysfunctional in PD by discussing the possible role of gut microbiota, inflammation and permeability in the development of the disease.
目前已经明确，帕金森病（PD）不仅是中枢神经系统的运动障碍，也是影响肠神经系统（ENS）的胃肠道疾病。肠脑轴是大脑和胃肠道之间的双向通讯，除了中枢神经系统和肠神经系统外，还包括肠道上皮屏障、肠道微生物群和肠内分泌系统。在这篇综述中，我们通过讨论肠道微生物群、炎症和通透性在疾病发展中的可能作用，提出了肠道-脑轴在 PD 中功能失调的临床和病理证据。
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