Gokel J M, Reichart B, Struck E
Pathol Res Pract. 1985 Jan;179(3):354-64. doi: 10.1016/s0344-0338(85)80144-8.
From May 1981 through July 1984 a total of 29 human allogenic orthotopic cardiac transplants were performed in Munich. The first two patients initially received conventional immunosuppressive treatment for 79 and 27 days, respectively; then treatment was continued with cyclosporine. All subsequent 27 patients received only cyclosporine treatment. Seventeen of the cardiac recipients are currently alive. Three of the recipients who died succumbed to immunological rejection. Twenty-five cardiac grafts were controlled by 355 sequential biopsy procedures, which yielded 1158 endomyocardial specimens for histological examination. The morphological findings and changes observed in the endomyocardium were analyzed. The interpretation of these findings and difficulties encountered in their interpretation are discussed. Special attention is attributed to findings possibly associated with the cyclosporine treatment.
从1981年5月至1984年7月，慕尼黑共进行了29例人类同种异体原位心脏移植手术。最初的两名患者分别接受了79天和27天的传统免疫抑制治疗；然后继续使用环孢素治疗。随后的27例患者仅接受环孢素治疗。目前17名心脏移植受者存活。3名死亡的受者死于免疫排斥反应。通过355次连续活检程序对25例心脏移植物进行了监测，获取了1158份心内膜标本用于组织学检查。分析了心内膜中观察到的形态学发现和变化。讨论了这些发现的解释及其解释中遇到的困难。特别关注了可能与环孢素治疗相关的发现。
