School of Materials and Chemistry, University of Shanghai for Science and Technology, Shanghai, China.
Department of Prosthodontics, Shanghai Stomatological Hospital, Fudan University, Shanghai, China; Shanghai Key Laboratory of Craniomaxill of Acial Development and Diseases, Fudan University, Shanghai, China.
J Mech Behav Biomed Mater. 2024 Sep;157:106605. doi: 10.1016/j.jmbbm.2024.106605. Epub 2024 May 31.
Peri-implantitis and insufficient osseointegration are the principal challenges faced by dental implants at present. In order to fabricate dual-function dental implant materials possessing both antibacterial and osteogenic capabilities, this study incorporates the antimicrobial element Cu into the Ti40Nb alloy, developing a novel Ti40Nb-xCu alloy with antibacterial properties. Among them, Ti40Nb3Cu has the best overall performance. Compared to Ti40Nb, the tensile strength increased by 27.97%, reaching 613 MPa. Although the elongation rate has decreased from 23% to 13.5%, the antibacterial rates against S. aureus and P. gingivalis both exceed 85%. Furthermore, the surface of Ti40Nb-xCu alloy was then treated with micro-arc oxidation to enhance its bioactivity, thereby accelerating osseointegration. The results indicated that the MAO treatment retains the antibacterial properties of the Ti40Nb3Cu alloy while significantly promoting bone formation through its introduced porous coating, thus heralding it as a propitious candidate material for dental implant applications.
种植体周围炎和骨整合不足是目前牙科种植体面临的主要挑战。为了制备同时具有抗菌和成骨能力的双功能牙科植入材料，本研究将抗菌元素 Cu 引入 Ti40Nb 合金中，开发出一种具有抗菌性能的新型 Ti40Nb-xCu 合金。其中，Ti40Nb3Cu 的综合性能最佳。与 Ti40Nb 相比，其拉伸强度提高了 27.97%，达到 613 MPa。虽然伸长率从 23%下降到 13.5%，但对金黄色葡萄球菌和牙龈卟啉单胞菌的抑菌率均超过 85%。此外，还对 Ti40Nb-xCu 合金的表面进行了微弧氧化处理，以提高其生物活性，从而加速骨整合。结果表明，MAO 处理保留了 Ti40Nb3Cu 合金的抗菌性能，同时通过引入多孔涂层显著促进了骨形成，因此有望成为牙科植入物应用的候选材料。
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