Nevin N C
Prog Clin Biol Res. 1985;163B:389-96.
The British Isles multicentre study of periconceptional vitamin supplementation in women with a previous infant with an NTD has demonstrated an apparent beneficial effect in reducing risk of recurrence of an NTD. In Northern Ireland, a similar significant effect has been observed with a reduction of the recurrence risk from 5.2% in unsupplemented to 0.7% in fully supplemented women. The problems and implications of periconceptional vitamin supplementation in the prevention of NTDs are discussed.
对曾生育过神经管缺陷患儿的女性进行围孕期维生素补充的不列颠群岛多中心研究表明，在降低神经管缺陷复发风险方面有明显的有益效果。在北爱尔兰，也观察到了类似的显著效果，未补充维生素的女性复发风险为5.2%，而完全补充维生素的女性复发风险降至0.7%。本文讨论了围孕期补充维生素在预防神经管缺陷方面的问题及影响。
