Massachusetts Institute of Technology, USA.
J Biomech. 2024 Jun;171:112174. doi: 10.1016/j.jbiomech.2024.112174. Epub 2024 May 24.
We have studied wound contraction in three model wounds in animals: excised skin (guinea pig), transected peripheral nerve (rat) and the excised conjunctiva (rabbit). Wound contraction is driven by myofibroblasts bound together by adherens junctions (AJ) that confer cooperative activity to myofibroblasts during wound contraction and synthesis of scar. Grafting with the dermis regeneration template (DRT) cancels cell cooperativity by abolishing AJ connections in myofibroblasts, while also cancelling wound contraction, preventing synthesis of scar and inducing regeneration of excised tissues. The observed definitive prevention of scar synthesis suggests the exploration of DRT scaffolds to regenerate tissues in several other organs and to prevent fibrosis in humans.
切除的皮肤（豚鼠）、横断的周围神经（大鼠）和切除的结膜（兔子）。伤口收缩是由通过黏着连接（AJ）结合在一起的肌成纤维细胞驱动的，这些连接在伤口收缩和瘢痕合成过程中赋予肌成纤维细胞协同作用。用真皮再生模板（DRT）进行移植通过消除肌成纤维细胞中的 AJ 连接来取消细胞的协同作用，同时还会取消伤口收缩、防止瘢痕合成，并诱导切除组织的再生。观察到明确预防瘢痕合成表明，应该探索 DRT 支架来再生几个其他器官的组织，并预防人类的纤维化。
