Pharmacy College, Henan University of Chinese Medicine, 450046 Zhengzhou, PR China.
Pharmacy College, Henan University of Chinese Medicine, 450046 Zhengzhou, PR China.
Bioorg Med Chem Lett. 2024 Sep 1;109:129845. doi: 10.1016/j.bmcl.2024.129845. Epub 2024 Jun 7.
Cyclopropenone is a valuable electrophilic reagent that can react with electrophilic reagents, nucleophilic reagents, free radicals, organic metals, etc. Furthermore, cyclopropenone derivatives have shown significant biological activity in various diseases, such as triple-negative breast cancer (TNBC), melanoma, and alopecia areata (AA). The cyclopropenone analogue diphenylcyclopropenone (DPCP) has been approved for the treatment of AA. Given the potential therapeutic benefits of cyclopropenone derivatives, this review aims to systematically summarize the structures, synthesis routes, and potential pharmacological functions of cyclopropenone analogues in the hope of offering novel insights for further rational design of more drugs based on the cyclopropenone skeleton for the treatment of human diseases.
环丙烯酮是一种有价值的亲电试剂，可与亲电试剂、亲核试剂、自由基、有机金属等反应。此外，环丙烯酮衍生物在各种疾病中表现出显著的生物活性，如三阴性乳腺癌（TNBC）、黑色素瘤和斑秃（AA）。环丙烯酮类似物二苯基环丙烯酮（DPCP）已被批准用于治疗 AA。鉴于环丙烯酮衍生物的潜在治疗益处，本综述旨在系统总结环丙烯酮类似物的结构、合成路线和潜在的药理学功能，希望为进一步基于环丙烯酮骨架合理设计更多治疗人类疾病的药物提供新的见解。
