外用二苯环丙烯酮治疗广泛性斑秃。
The use of topical diphenylcyclopropenone for the treatment of extensive alopecia areata.
作者信息
Cotellessa C, Peris K, Caracciolo E, Mordenti C, Chimenti S
机构信息
Department of Dermatology, University of L'Aquila, Italy.
出版信息
J Am Acad Dermatol. 2001 Jan;44(1):73-6. doi: 10.1067/mjd.2001.109309.
BACKGROUND
Highly variable results of topical diphenylcyclopropenone (DPCP) in the treatment of alopecia areata have been reported so far.
OBJECTIVE
The purposes of our study were to evaluate the efficacy and tolerability of DPCP in the treatment of chronic, extensive alopecia areata and to assess the long-term overall benefit of treatment.
METHODS
Fifty-six patients with chronic, extensive alopecia areata were enrolled in an open-label clinical trial. After sensitization with 2% DPCP, progressively higher concentrations beginning at 0.001% were applied weekly for 6 to 12 months to one side of the scalp.
RESULTS
Fifty-two of 56 patients completed therapy. Total regrowth of terminal hair was achieved in 25 of 52 patients (48%) at 6 months. The most frequent side effect was an eczematous reaction at the site of application. Notably, persistent response was observed in 60% of these patients after 6 to 18 months of follow-up (mean, 12 months).
CONCLUSION
Topical DPCP treatment for alopecia areata is effective and well tolerated and provides prolonged therapeutic benefits.
背景
迄今为止，已有报道称外用二苯环丙烯酮（DPCP）治疗斑秃的结果差异很大。
目的
我们研究的目的是评估DPCP治疗慢性广泛性斑秃的疗效和耐受性，并评估治疗的长期总体益处。
方法
56例慢性广泛性斑秃患者参加了一项开放标签的临床试验。在用2% DPCP致敏后，从0.001%开始，每周在头皮一侧应用逐渐升高浓度的药物，持续6至12个月。
结果
56例患者中有52例完成了治疗。52例患者中有25例（48%）在6个月时终毛完全再生。最常见的副作用是用药部位的湿疹样反应。值得注意的是，在随访6至18个月（平均12个月）后，这些患者中有60%观察到持续反应。
结论
外用DPCP治疗斑秃有效且耐受性良好，并能提供长期的治疗益处。
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