Root-knot nematodes, genus , are the most damaging nematodes of sweet potato, causing yield reduction and aesthetic damage of the marketable product. Several sweet potato cultivars currently grown in the Unites States have intermediate-to-high resistance to ; however, many of these cultivars are susceptible to . Therefore, the response of 69 sweet potato genotypes to and was evaluated under greenhouse conditions to identify potential sources of resistance. The cultivars 'Beauregard' and 'Jewel' were used as controls. Results showed that sweet potato genotypes were either highly resistant or highly susceptible to , whereas they showed a wide-spectrum response to , ranging from highly susceptible to highly resistant. Twenty-six genotypes were resistant to and 11 genotypes were resistant to . Combined resistance to and was observed in three sweet potato genotypes. Selected genotypes from this study will be used to incorporate the observed resistance into a commercially viable sweet potato cultivar.