Bae Gaeun, Cho Hyeonwoo, Hong Byung Hee
Department of Chemistry, Seoul National University (SNU), Seoul 08826, Republic of Korea.
Nanotechnology. 2024 Jun 28;35(37). doi: 10.1088/1361-6528/ad55d0.
A new type of 0-dimensional carbon-based materials called graphene quantum dots (GQDs) is gaining significant attention as a non-toxic and eco-friendly nanomaterial. GQDs are nanomaterials composed of sphybridized carbon domains and functional groups, with their lateral size less than 10 nm. The unique and exceptional physical, chemical, and optical properties arising from the combination of graphene structure and quantum confinement effect due to their nano-size make GQDs more intriguing than other nanomaterials. Particularly, the low toxicity and high solubility derived from the carbon core and abundant edge functional groups offer significant advantages for the application of GQDs in the biomedical field. In this review, we summarize various synthetic methods for preparing GQDs and important factors influencing the physical, chemical, optical, and biological properties of GQDs. Furthermore, the recent application of GQDs in the biomedical field, including biosensor, bioimaging, drug delivery, and therapeutics are discussed. Through this, we provide a brief insight on the tremendous potential of GQDs in biomedical applications and the challenges that need to be overcome in the future.
一种新型的零维碳基材料——石墨烯量子点（GQDs），作为一种无毒且环保的纳米材料正受到广泛关注。石墨烯量子点是由sp杂化碳域和官能团组成的纳米材料，其横向尺寸小于10纳米。由于其纳米尺寸，石墨烯结构与量子限域效应相结合产生了独特而优异的物理、化学和光学性质，这使得石墨烯量子点比其他纳米材料更具吸引力。特别是，由碳核心和丰富的边缘官能团产生的低毒性和高溶解性，为石墨烯量子点在生物医学领域的应用提供了显著优势。在这篇综述中，我们总结了制备石墨烯量子点的各种合成方法以及影响石墨烯量子点物理、化学、光学和生物学性质的重要因素。此外，还讨论了石墨烯量子点在生物医学领域的最新应用，包括生物传感器、生物成像、药物递送和治疗。通过本文，我们简要介绍了石墨烯量子点在生物医学应用中的巨大潜力以及未来需要克服的挑战。
