Barrientos Kaory, Arango Juan Pablo, Moncada Manuel Santiago, Placido Jersson, Patiño Juliana, Macías Sara Legny, Maldonado Camilo, Torijano Sandra, Bustamante Sandra, Londoño Martha Elena, Jaramillo Marisol
GIBEC Research Group. Life Sciences Faculty. Universidad EIA, Calle 25 Sur # 42-73, Medellín, Colombia.
GIBEC Research Group. Life Sciences Faculty. Universidad EIA, Calle 25 Sur # 42-73, Medellín, Colombia.
Talanta. 2023 Jan 1;251:123791. doi: 10.1016/j.talanta.2022.123791. Epub 2022 Aug 5.
Due to their fascinating chemical, optical, electrical, and biological properties carbon dots (CDs or CDots), carbon quantum dots (CQDs), and graphene quantum dots (GQDs) have attracted attention in biosensing as they can greatly improve the detection limit, sensitivity, and selectivity of biosensors. In general, CDs, CQDs, and GQDs are a class of carbon-based nanomaterials that are characterized by extraordinary fluorescence, a size less than 10 nm, high stability, low toxicity, and being easy to synthesize and presenting functional groups in their surface area that vary according to their synthesis source. In this review, a general description of the main methods and precursors reported in the scientific literature for the synthesis of CDs, CQDs, and GQDs are presented, as well as the chemical, optical, electrical, and biological properties that stand out the most from them; moreover, the main objective of this review is to summarize the application of these carbonaceous nanomaterials in biosensors for the detection of communicable and non-communicable diseases. The article summarizes the applications of CDs, CQDs, and GQDs according to the group of diseases they detected using the international classification of diseases in its 10th edition (ICD-10). To facilitate the reader's access to significant information from these biosensors, several tables summarize the information associated with the type of biomarker, the working ranges, and the biosensor assembly.
由于具有迷人的化学、光学、电学和生物学特性，碳点（CDs或CDots）、碳量子点（CQDs）和石墨烯量子点（GQDs）在生物传感领域引起了关注，因为它们可以极大地提高生物传感器的检测限、灵敏度和选择性。一般来说，CDs、CQDs和GQDs是一类碳基纳米材料，其特点是具有非凡的荧光、尺寸小于10纳米、高稳定性、低毒性，易于合成且其表面积上存在根据合成来源而变化的官能团。在本综述中，介绍了科学文献中报道的用于合成CDs、CQDs和GQDs的主要方法和前驱体的一般描述，以及它们最突出的化学、光学、电学和生物学特性；此外，本综述的主要目的是总结这些碳质纳米材料在用于检测传染病和非传染病的生物传感器中的应用。本文根据使用第十版国际疾病分类（ICD - 10）检测的疾病类别总结了CDs、CQDs和GQDs的应用。为方便读者获取这些生物传感器的重要信息，几个表格总结了与生物标志物类型、工作范围和生物传感器组件相关的信息。
