Barati Fatemeh, Avatefi Manizheh, Moghadam Negin Borzooee, Asghari Sahar, Ekrami Elena, Mahmoudifard Matin
Department of Industrial and Environmental Biotechnology, 48482National Institute for Genetic Engineering and Biotechnology, Tehran, Iran.
J Biomater Appl. 2023 Feb;37(7):1137-1158. doi: 10.1177/08853282221125311. Epub 2022 Sep 6.
Today, nanobiotechnology is a pioneering technology in biomedicine. Every day, new nanomaterials are synthesized with elevated physiochemical properties for better diagnosis and treatment of diseases. One advancing class of materials is the Graphene family. Among different kinds of graphene derivatives, graphene quantum dots (GQDs) show fantastic optical, electrical, and electrochemical features originating from their unique quantum confinement effect. Due to the distinct properties of GQD, including large surface-to-volume ratio, low cytotoxicity, and easy functionalization, this nanomaterial has gone popular in biomedical field. Herein, a short overview of different strategies developed for GQD synthesis and functionalization is discussed. In the following, the most recent progress of GQD based nanomaterials in different biomedical fields, including bio-imaging, drug/gene delivery, antimicrobial, tissue engineering, and biosensors, are reviewed.
如今，纳米生物技术是生物医学领域的一项前沿技术。每天都有具有更高理化性质的新型纳米材料被合成出来，用于疾病的更好诊断和治疗。一类正在发展的材料是石墨烯家族。在不同种类的石墨烯衍生物中，石墨烯量子点（GQDs）因其独特的量子限制效应而展现出出色的光学、电学和电化学特性。由于GQD具有诸如大的表面积与体积比、低细胞毒性和易于功能化等独特性质，这种纳米材料在生物医学领域已广受欢迎。本文讨论了为GQD合成和功能化所开发的不同策略的简要概述。接下来，将综述基于GQD的纳米材料在不同生物医学领域，包括生物成像、药物/基因递送、抗菌、组织工程和生物传感器等方面的最新进展。
