Howe Matthew D, Caruso Megan R, Manoochehri Masood, Kunicki Zachary J, Emrani Sheina, Rudolph James L, Huey Edward D, Salloway Stephen P, Oh Hwamee
medRxiv. 2024 May 28:2024.05.28.24308056. doi: 10.1101/2024.05.28.24308056.
The relationship between cerebrovascular disease (CVD) and amyloid-β (Aβ) in Alzheimer disease (AD) is understudied. We hypothesized that magnetic resonance imaging (MRI)-based CVD biomarkers, including cerebral microbleeds (CMBs), ischemic infarction, and white matter hyperintensities (WMH), would correlate with Aβ positivity on positron emission tomography (Aβ-PET).
We cross-sectionally analyzed data from the Alzheimer's Disease Neuroimaging Initiative (ADNI, N=1,352). Logistic regression was used to calculate odds ratios (ORs), with Aβ-PET positivity as the standard-of-truth.
Following adjustment, WMH (OR=1.25) and superficial CMBs (OR=1.45) remained positively associated with Aβ-PET positivity (p<.001). Deep CMBs and infarcts exhibited a varied relationship with Aβ-PET in cognitive subgroups. The combined diagnostic model, which included CVD biomarkers and other accessible measures, significantly predicted Aβ-PET (pseudo-R =.41).
The study highlights the translational value of CVD biomarkers in diagnosing AD, and underscores the need for more research on their inclusion in diagnostic criteria. ADNI-2 ( NCT01231971 ), ADNI-3 ( NCT02854033 ).
脑血管疾病（CVD）与阿尔茨海默病（AD）中的β淀粉样蛋白（Aβ）之间的关系研究不足。我们假设基于磁共振成像（MRI）的CVD生物标志物，包括脑微出血（CMB）、缺血性梗死和白质高信号（WMH），将与正电子发射断层扫描（Aβ-PET）上的Aβ阳性相关。
我们对来自阿尔茨海默病神经影像倡议（ADNI，N = 1352）的数据进行了横断面分析。使用逻辑回归计算比值比（OR），以Aβ-PET阳性作为真值标准。
调整后，WMH（OR = 1.25）和浅表CMB（OR = 1.45）与Aβ-PET阳性仍呈正相关（p <.001）。深部CMB和梗死在认知亚组中与Aβ-PET表现出不同的关系。包括CVD生物标志物和其他可获取测量指标的联合诊断模型显著预测了Aβ-PET（伪R = 0.41）。
该研究强调了CVD生物标志物在AD诊断中的转化价值，并强调了对将其纳入诊断标准进行更多研究的必要性。ADNI-2（NCT01231971），ADNI-3（NCT02854033）。
