McDonald Robert C, Fischer Andrew H, Rusckowski Mary
Giner, Inc. 89 Rumford Avenue Newton, MA 02466-1311.
University of Massachusetts Medical School, Director, Cytopathology.
bioRxiv. 2024 Jun 1:2024.05.27.596060. doi: 10.1101/2024.05.27.596060.
An oxygen sensor-mounted fine-needle biopsy tool was used for measurement of oxygen levels in tumor xenografts. The system provides a means of measuring the oxygen content in harvested tumor tissue from specific locations. Oxygen in human tumor xenografts in a murine model was observed for over 1 min. Tissues were mapped in relation to oxygen tension (pO) readings and sampled for conventional cytological examination. Careful modeling of the pO readings over 60 seconds yielded a diffusion coefficient for oxygen at the sensor tip, providing additional diagnostic information about the tissue before sampling. Oxygen level measurement may provide a useful adjunct to the use of biomarkers in tumor diagnosis.
一种安装了氧传感器的细针活检工具被用于测量肿瘤异种移植中的氧水平。该系统提供了一种测量从特定位置采集的肿瘤组织中氧含量的方法。在小鼠模型中对人肿瘤异种移植中的氧进行了超过1分钟的观察。根据氧张力（pO）读数对组织进行定位，并取样进行常规细胞学检查。对60秒内的pO读数进行仔细建模，得出了传感器尖端处氧的扩散系数，在取样前提供了有关组织的额外诊断信息。氧水平测量可能为肿瘤诊断中生物标志物的使用提供有用的辅助手段。
