Wise R A
South Med J. 1985 Apr;78(4):423-8. doi: 10.1097/00007611-198504000-00017.
Cardiac output is determined by the interaction of cardiac pump function and the mechanical properties of the peripheral circulation that govern venous return. Increasing pleural pressure impedes peripheral venous return but aids cardiac ejection; on the other hand, decreasing pleural pressure can augment venous return but impedes the emptying of the left ventricle, creating an increase in aortic pressure. Whether a fall in pleural pressure leads to an increase or decrease in cardiac output depends upon the functional state of the heart and its sensitivity to changes in afterload. Understanding the effect of pleural pressure on cardiac output may lead to the development of therapeutic or diagnostic techniques using altered pleural pressure.
心输出量由心脏泵功能与控制静脉回流的外周循环机械特性之间的相互作用决定。胸膜腔内压升高会阻碍外周静脉回流，但有助于心脏射血；另一方面，胸膜腔内压降低可增加静脉回流，但会阻碍左心室排空，导致主动脉压升高。胸膜腔内压下降导致心输出量增加还是减少取决于心脏的功能状态及其对后负荷变化的敏感性。了解胸膜腔内压对心输出量的影响可能会促使人们开发利用改变胸膜腔内压的治疗或诊断技术。
