Gaydarski Lyubomir, Landzhov Boycho, Kamenov Ivaylo, Ananiev Julian M, Georgiev Georgi P
Department of Anatomy, Histology and Embryology, Medical University of Sofia, Sofia, BGR.
Department of Orthopedics and Traumatology, University Hospital Queen Giovanna-ISUL, Sofia, BGR.
Cureus. 2024 May 9;16(5):e59943. doi: 10.7759/cureus.59943. eCollection 2024 May.
Hibernomas, rare benign tumors originating from brown adipose tissue, pose diagnostic challenges due to their infrequent occurrence and slow growth. We present a case of a 38-year-old woman with a progressively enlarging mass in her right lateral chest wall, initially stable in size but growing during pregnancy and causing pain and functional impairment. Radiological evaluation, including x-ray and MRI, provided inconclusive results, necessitating a biopsy for a definitive diagnosis. Ultrasound-guided needle aspiration biopsy revealed typical histopathological features consistent with hibernoma. A subsequent total surgical excision with negative margins was performed. The patient achieved complete recovery without recurrence during two years of follow-up. This case underscores the importance of considering hibernoma in the differential diagnosis of adipose tissue tumors, particularly in atypical clinical presentations. Moreover, it highlights the challenges in diagnosing and managing hibernomas and emphasizes the role of MRI and biopsy in achieving accurate diagnosis and optimal treatment outcomes. Continued reporting of such cases is crucial for increasing awareness and improving the management of this rare tumor.
冬眠瘤是起源于棕色脂肪组织的罕见良性肿瘤,因其发病率低且生长缓慢而带来诊断挑战。我们报告一例38岁女性病例,其右外侧胸壁有一逐渐增大的肿块,肿块大小起初稳定,但在孕期增大,引起疼痛和功能障碍。包括X线和磁共振成像(MRI)在内的影像学评估结果不明确,需要进行活检以明确诊断。超声引导下针吸活检显示出与冬眠瘤一致的典型组织病理学特征。随后进行了切缘阴性的完整手术切除。患者在两年随访期间完全康复且无复发。该病例强调了在脂肪组织肿瘤的鉴别诊断中考虑冬眠瘤的重要性,尤其是在非典型临床表现中。此外,它突出了冬眠瘤诊断和管理中的挑战,并强调了MRI和活检在实现准确诊断和最佳治疗结果方面的作用。持续报告此类病例对于提高对此罕见肿瘤的认识和改善其管理至关重要。