Wang Baocheng, Wei Xuelian, Zhou Hanlin, Cao Xiaole, Zhang Enyang, Wang Zhong Lin, Wu Zhiyi
Beijing Institute of Nanoenergy and Nanosystems Chinese Academy of Sciences Beijing China.
School of Nanoscience and Technology University of Chinese Academy of Sciences Beijing China.
Exploration (Beijing). 2023 Nov 23;4(1):20230073. doi: 10.1002/EXP.20230073. eCollection 2024 Feb.
Thromboelastography (TEG) remains a convenient and effective viscoelastic blood coagulation testing device for guiding blood component transfusion and assessing the risk of thrombosis. Here, a TEG enabled by a non-contact triboelectric angle sensor (NTAS) with a small size (∼7 cm) is developed for assessing the blood coagulation system. With the assistance of a superelastic torsion wire structure, the NTAS-TEG realizes the detection of blood viscoelasticity. Benefiting from a grating and convex design, the NTAS holds a collection of compelling features, including accurate detection of rotation angles from -2.5° to 2.5°, high linearity ( = 0.999), and a resolution of 0.01°. Besides, the NTAS exhibits merits of low cost and simplified fabrication. Based on the NTAS-TEG, a viscoelastic blood coagulation detection and analysis system is successfully constructed, which can provide a graph and parameters associated with clot initiation, formation, and stability for clinicians by using 0.36 mL of whole blood. The system not only validates the feasibility of the triboelectric coagulation testing sensor, but also further expands the application of triboelectric sensors in healthcare.
血栓弹力图（TEG）仍然是一种方便有效的粘弹性血液凝固检测设备，用于指导血液成分输血和评估血栓形成风险。在此，开发了一种由非接触式摩擦电角度传感器（NTAS）实现的小型（约7厘米）TEG，用于评估血液凝固系统。在超弹性扭线结构的辅助下，NTAS-TEG实现了对血液粘弹性的检测。得益于光栅和凸面设计，NTAS具有一系列引人注目的特性，包括精确检测-2.5°至2.5°的旋转角度、高线性度（ = 0.999）以及0.01°的分辨率。此外，NTAS还具有低成本和制造工艺简化的优点。基于NTAS-TEG，成功构建了一种粘弹性血液凝固检测与分析系统，该系统使用0.36 mL全血可为临床医生提供与凝血起始、形成和稳定性相关的图表和参数。该系统不仅验证了摩擦电凝血检测传感器的可行性，还进一步拓展了摩擦电传感器在医疗保健领域的应用。
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