Zhang Xiaoling, Bai Yaqi, Liu Shiping, Yang Jun, Hu Ning
School of Smart Health, Chongqing College of Electronic Engineering, Chongqing 401331, China.
Key Laboratory of Biorheological Science and Technology, Ministry of Education and Bioengineering College, Chongqing University, Chongqing 400044, China.
ACS Omega. 2024 May 19;9(22):24050-24059. doi: 10.1021/acsomega.4c02630. eCollection 2024 Jun 4.
Glass nanopipettes, as important sensing tools, have attracted great interest due to their wide range of applications in detecting single molecules, nanoparticles, and cells. In this study, we investigated the translocation behavior of nanorod particles through dual-nanopipettes using a transient continuum-based model based on an arbitrary Lagrangian-Eulerian approach. Our findings indicate that the translocation of nanorods is slowed down in the dual-nanopipette system, especially in the dual-nanopipette system with a nanobridge. These results are in qualitative agreement with previous experimental findings reported in the literature. Additionally, the translocation of nanorods is influenced by factors such as bulk concentration, initial location of the nanorod, and surface charge of the nanopipette. Notably, when the surface charge density of the nanopipette is relatively high and the initial location of the nanorod is in the reservoir, the nanorod can hardly enter the nanopipette, resulting in a relatively low translocation efficiency. However, the translocation efficiency can be improved by initially positioning the nanorod in one of the barrels. The resulting dual-blockade current signal can be used to correlate the characteristics of the nanorod.
玻璃纳米吸管作为重要的传感工具，因其在检测单分子、纳米颗粒和细胞方面的广泛应用而备受关注。在本研究中，我们使用基于任意拉格朗日 - 欧拉方法的瞬态连续介质模型，研究了纳米棒颗粒通过双纳米吸管的转运行为。我们的研究结果表明，在双纳米吸管系统中，尤其是在带有纳米桥的双纳米吸管系统中，纳米棒的转运速度会减慢。这些结果与文献中先前报道的实验结果在定性上一致。此外，纳米棒的转运受诸如本体浓度、纳米棒的初始位置和纳米吸管的表面电荷等因素影响。值得注意的是，当纳米吸管的表面电荷密度相对较高且纳米棒的初始位置在储液器中时，纳米棒几乎无法进入纳米吸管，导致转运效率相对较低。然而，通过将纳米棒最初放置在其中一个管腔中，可以提高转运效率。由此产生的双阻断电流信号可用于关联纳米棒的特性。
