Department of Internal Medicine, Medical Research and Clinical Studies Institute, National Research Center, Giza 12311, Egypt.
World J Gastroenterol. 2024 May 28;30(20):2633-2637. doi: 10.3748/wjg.v30.i20.2633.
This editorial builds on the article titled "Establishment and validation of an adherence prediction system for lifestyle interventions in non-alcoholic fatty liver disease" by Zeng . We carried out a critical examination of nonalcoholic fatty liver disease (NAFLD) pathogenesis and how lifestyle interventions could facilitate disease resolution, particularly highlighting that non-alcoholic steatohepatitis (NASH) is a severe form of NAFLD. Our discussion details that weight loss is a pivotal factor in disease outcomes: A 3%-5% reduction is enough for resolution in 50% of non-obese individuals, while a 7%-10% reduction achieves similar benefits in obese individuals, as demonstrated by magnetic resonance spectroscopy. Additionally, the editorial underscores that such lifestyle changes are instrumental not only in resolving NAFLD but also in reversing hepatic steatosis and inflammation. These insights, derived from the research, emphasize the critical role of personalized lifestyle modifications in halting the progression of NAFLD to NASH and even reversing fibrosis, thus offering a template for effective patient management.
这篇社论是对曾发表的题为“建立和验证非酒精性脂肪性肝病生活方式干预依从性预测系统”的文章的扩展。我们对非酒精性脂肪性肝病 (NAFLD) 的发病机制以及生活方式干预如何促进疾病的缓解进行了批判性的检查，特别强调非酒精性脂肪性肝炎 (NASH) 是一种严重的 NAFLD 形式。我们的讨论详细说明了体重减轻是疾病结果的关键因素：对于 50%的非肥胖个体，减轻 3%-5%就足以解决问题，而对于肥胖个体，减轻 7%-10%则可达到类似的效果，这一点已经通过磁共振光谱法得到了证实。此外，社论还强调，这些生活方式的改变不仅有助于解决 NAFLD，还可以逆转肝脂肪变性和炎症。这些研究结果强调了个性化生活方式改变在阻止 NAFLD 进展为 NASH 甚至逆转纤维化方面的关键作用，为有效的患者管理提供了模板。
