Wang Jingwei, Zhao Jinli, Zhong Yueyuan, He Chengyue, Hu Fen
Health Management Center, Affiliated Nanhua Hospital, University of South China, Hengyang, China.
School of Pharmaceutical Science, University of South China, Hengyang, China.
Clin Transl Gastroenterol. 2025 Feb 1;16(2):e00806. doi: 10.14309/ctg.0000000000000806.
Obesity is the primary cause of metabolic dysfunction-associated steatotic liver disease (MASLD). Healthy lifestyle management has potential value in the treatment of MASLD.
A total of 150 patients with MASLD diagnosed at the Health Management Center of our hospital were enrolled and randomly divided into a traditional treatment (control group, n = 75) and a healthy lifestyle group (observation group, n = 75). All patients underwent a 3-month intervention. Data on general information, body composition, glucose metabolism, lipid metabolism, and inflammatory factors were analyzed.
The difference in the change in fatty liver grade was statistically significant ( P < 0.05). There were statistically significant differences in treatment efficiency for physical conditions ( P < 0.05), including body fat mass, body mass index, body weight, waist circumference, and waist-to-hip ratio. In addition, there were statistically significant differences in treatment efficiency for scales such as the Diet Rating Scale, Emotional Stress Scale, and Global Physical Activity Questionnaire ( P < 0.05). Differences in treatment efficiency for body fat parameters, including percentage of body fat, visceral fat area, aspartate aminotransferase, and diastolic blood pressure, were also statistically significant ( P < 0.05). After treatment, statistically significant differences were observed in interferon-γ, insulin, low-density lipoprotein cholesterol, triglycerides, and tumor necrosis factor-α ( P < 0.05).
Our study indicates that a healthy lifestyle can effectively promote the reduction of fatty liver grade in patients with MASLD, demonstrating positive effects in improving lipid metabolism and inflammatory responses in these patients.
肥胖是代谢功能障碍相关脂肪性肝病（MASLD）的主要病因。健康的生活方式管理在MASLD的治疗中具有潜在价值。
选取我院健康管理中心确诊的150例MASLD患者，随机分为传统治疗组（对照组，n = 75）和健康生活方式组（观察组，n = 75）。所有患者均接受为期3个月的干预。分析患者的一般信息、身体成分、糖代谢、脂代谢及炎症因子等数据。
脂肪肝分级变化差异有统计学意义（P < 0.05）。身体状况的治疗有效率差异有统计学意义（P < 0.05），包括体脂量、体重指数、体重、腰围和腰臀比。此外，饮食评分量表、情绪压力量表和全球体力活动问卷等量表的治疗有效率差异有统计学意义（P < 0.05）。体脂参数的治疗有效率差异也有统计学意义，包括体脂百分比、内脏脂肪面积、天冬氨酸转氨酶和舒张压（P < 0.05）。治疗后，干扰素-γ、胰岛素、低密度脂蛋白胆固醇、甘油三酯和肿瘤坏死因子-α差异有统计学意义（P < 0.05）。
我们的研究表明，健康的生活方式可有效促进MASLD患者脂肪肝分级的降低，对改善这些患者的脂代谢和炎症反应具有积极作用。
