Elsharkawi Adel S A, Elazab Huda A, Askar Mostafa A, Abdelrahman Ibrahim Y, Arafa Amany A, Gomma Lofty R, Lo Yu-Lung
Department of Radiation Engineering, National Center for Radiation Research and Technology (NCRRT), Egyptian Atomic Energy Authority, Cairo 11787, Egypt.
Department of Mechanical Engineering, National Cheng Kung University, Tainan 701, Taiwan.
Biomed Opt Express. 2024 Apr 30;15(5):3492-3506. doi: 10.1364/BOE.523849. eCollection 2024 May 1.
This study introduces a cutting-edge fiber-optic dosimetry (FOD) sensor designed for measuring radiation in biological settings. The accuracy and precision of dosimeters for small animals, particularly prolonged exposure to nonuniform radiation fields, are always challenging. A state-of-the-art dosimeter utilizing glass-encapsulated Thermoluminescence cylindrical detector (TLD) was introduced. The FODs are implanted into the rat during a prolonged irradiation scenario involving Cs where the rat has the freedom to move within a heterogeneous radiation domain. The implantation surgery was verified with X-ray computed tomography (CT) in addition to biochemical and pathological tests to assess the biocompatibility of FOD vivo. A versatile FOD is designed for industrial and medical fields, which demand accurate and resilient radiation dosimeters. The dose measurements are associated with precise two-dimensional (2D) radiation distribution imaging. Three cylindrical FODs and three standards TLD_100 for each rat were tested. The measurements of peak irradiation before and after exposure reveal greater stability and superior sensitivity when compared to standard thermo-luminescence detectors in an in-vivo animal test. To the best of our knowledge, FOD testing on live animals is presented for the first time in this paper. Regarding the safety and biocompatibility of FOD, no morphological signs with any kind of inflammation or sensitivity toward the FOD material have been remarked. Moreover, with the current FOD, there is no oedema between the epidermal, dermal, and subdermal sections at the site of implantation. The results also show the stable levels of white blood cells (lymphocytes, granulocytes, MID) as blood inflammatory markers before surgery and at the time of extraction of the implanted dosimeters, thus confirming the biocompatibility for each optical fiber cylinder dosimeter. As a result, the new dosimeters have excellent biocompatibility in living tissues and have 100% accurate reusability intensity of the delivered radiation doses compared to TLD_100 which demonstrated a 45% reduction in its intensity accuracy.
本研究介绍了一种用于测量生物环境中辐射的前沿光纤剂量测定（FOD）传感器。小动物剂量计的准确性和精度，尤其是长时间暴露于非均匀辐射场时，一直是个挑战。本文介绍了一种利用玻璃封装热释光圆柱形探测器（TLD）的先进剂量计。在涉及铯的长时间辐照场景中，将FOD植入大鼠体内，大鼠可在异质辐射域内自由移动。除了生化和病理测试以评估FOD在体内的生物相容性外，还通过X射线计算机断层扫描（CT）对植入手术进行了验证。一种通用的FOD专为工业和医疗领域设计，这些领域需要精确且耐用的辐射剂量计。剂量测量与精确的二维（2D）辐射分布成像相关。对每只大鼠测试了三个圆柱形FOD和三个标准TLD_100。与标准热释光探测器相比，在体内动物测试中，暴露前后的峰值辐照测量显示出更高的稳定性和卓越的灵敏度。据我们所知，本文首次展示了在活体动物上进行的FOD测试。关于FOD的安全性和生物相容性，未观察到任何对FOD材料有炎症或敏感的形态学迹象。此外，使用当前的FOD，植入部位的表皮、真皮和皮下组织之间没有水肿。结果还显示，作为血液炎症标志物的白细胞（淋巴细胞、粒细胞、中间细胞）在手术前和植入剂量计取出时的水平稳定，从而证实了每个光纤圆柱体剂量计的生物相容性。因此，与TLD_100相比，新剂量计在活组织中具有出色的生物相容性，并且所传递辐射剂量的可重复使用强度100%准确，而TLD_100的强度准确性降低了45%。
