Department of Chinese Medicine, The Fourth Hospital of Changsha, Changsha, Hunan, China.
Eur Rev Med Pharmacol Sci. 2024 May;28(10):3607-3614. doi: 10.26355/eurrev_202405_36297.
The impact of particulate matter (PM) on the risk of type 2 diabetes (T2D) remains inconclusive. The purpose of this study was to assess the causal relationship between PM and T2D using Mendelian randomization (MR) analysis.
Single nucleotide polymorphisms (SNPs) for PM2.5, PM10, and T2D were obtained from the UK Biobank and FinnGen datasets. Inverse variance weighted, MR-Egger, and weighted median were utilized to examine the causal relationship between exposure and outcome. MR-Egger intercept analysis, Cochran's Q test, and leave-one-out sensitivity analysis were used to assess horizontal pleiotropy, heterogeneity, and robustness of the results, respectively.
The MR analysis revealed a significant association between PM2.5 and increased risk of T2D (OR: 1.159, 95% CI: 1.003 to 1.339, p = 0.045), while no significant association was found between PM10 and T2D risk (OR: 1.031, 95% CI: 0.788 to 1.350, p = 0.822). MR-Egger intercept analysis and Cochran's Q test indicated no evidence of horizontal pleiotropy or heterogeneity in these results. Sensitivity analysis demonstrated the robustness of the results.
This MR analysis suggests that PM2.5, rather than PM10, is associated with an increased risk of T2D. The use of air purifiers and anti-smog masks may potentially help reduce the risk of T2D. Further research is needed to elucidate the specific effects and underlying mechanisms of PM2.5 and PM10 on T2D.
颗粒物（PM）对 2 型糖尿病（T2D）风险的影响仍不确定。本研究旨在通过孟德尔随机化（MR）分析评估 PM 与 T2D 之间的因果关系。
从英国生物银行和芬兰基因数据集获得了用于 PM2.5、PM10 和 T2D 的单核苷酸多态性（SNP）。使用逆方差加权、MR-Egger 和加权中位数来检验暴露与结局之间的因果关系。MR-Egger 截距分析、Cochran's Q 检验和逐一剔除敏感性分析分别用于评估水平多效性、异质性和结果的稳健性。
MR 分析显示，PM2.5 与 T2D 风险增加显著相关（OR：1.159，95%CI：1.003 至 1.339，p = 0.045），而 PM10 与 T2D 风险之间无显著关联（OR：1.031，95%CI：0.788 至 1.350，p = 0.822）。MR-Egger 截距分析和 Cochran's Q 检验表明，这些结果中没有水平多效性或异质性的证据。敏感性分析表明结果稳健。
这项 MR 分析表明，PM2.5 而不是 PM10 与 T2D 风险增加相关。使用空气净化器和防烟雾口罩可能有助于降低 T2D 的风险。需要进一步研究以阐明 PM2.5 和 PM10 对 T2D 的具体影响和潜在机制。
