Complexity Science Group, Department of Physics and Astronomy, University of Calgary, Calgary, Alberta T2N 1N4, Canada.
Canadian Centre for Behavioral Neuroscience, University of Lethbridge, Lethbridge, Alberta T1K 3M4, Canada.
Phys Rev Lett. 2024 May 24;132(21):218403. doi: 10.1103/PhysRevLett.132.218403.
Sleep is characterized by nonrapid eye movement sleep, originating from widespread neuronal synchrony, and rapid eye movement sleep, with neuronal desynchronization akin to waking behavior. While these were thought to be global brain states, recent research suggests otherwise. Using time-frequency analysis of mesoscopic voltage-sensitive dye recordings of mice in a urethane-anesthetized model of sleep, we find transient neural desynchronization occurring heterogeneously across the cortex within a background of synchronized neural activity, in a manner reminiscent of a critical spreading process and indicative of an "edge-of-synchronization" phase transition.
睡眠的特征是非快速眼动睡眠，源自广泛的神经元同步，以及快速眼动睡眠，神经元去同步类似于清醒行为。虽然这些被认为是大脑的全局状态，但最近的研究表明并非如此。使用时间-频率分析，对处于睡眠的乌头酸麻醉模型的小鼠的介观电压敏感染料记录进行分析，我们发现，在同步的神经活动背景下，在皮层内异质地发生短暂的神经去同步，这种方式类似于一个临界传播过程，并表明存在一个“同步边缘”相变。
