姜黄素补充剂对焦虑症状的影响：随机对照试验的系统评价和荟萃分析。
Effect of curcumin supplementation on symptoms of anxiety: A systematic review and meta-analysis of randomized controlled trials.
机构信息
Department of Clinical Nutrition, School of Nutrition and Food Science, Isfahan University of Medical Sciences, Isfahan, Iran.
Department of Pharmacy, Shiraz University of Medical Sciences, Shiraz, Iran.
出版信息
Clin Nutr ESPEN. 2024 Aug;62:253-259. doi: 10.1016/j.clnesp.2024.05.017. Epub 2024 Jun 3.
BACKGROUND AND AIM
Curcumin is a polyphenolic natural compound that has been used to treat various ailments such as symptoms of anxiety. However, the findings of studies regarding the anti-anxiety properties of curcumin are controversial. This review aims to evaluate if there are clinical benefits of curcumin in patients with symptoms of anxiety.
METHODS
PubMed, Embase, Web of Science, and the Cochrane Library were retrieved to collect randomized controlled trials (RCTs) from the database inception to August 16, 2023. The random-effects model was used to estimate the standard mean difference (SMD).
RESULTS
A total of eight RCTs involving 567 participants were included in the analysis. A pooled analysis showed a significant effect of curcumin on anxiety symptoms (SMD: -1.56; 95% CI: -2.48, -0.64, p < 0.001; I = 95.6%, p-heterogeneity< 0.001).
CONCLUSION
Present meta-analysis demonstrated that curcumin intake might contribute to alleviation of anxiety disorder. Due to the limited number of studies included, it is necessary to conduct more high-quality studies to confirm the clinical efficacy of curcumin.
背景与目的
姜黄素是一种多酚类天然化合物，已被用于治疗各种疾病，如焦虑症状。然而，关于姜黄素抗焦虑特性的研究结果存在争议。本综述旨在评估姜黄素对有焦虑症状的患者是否具有临床益处。
方法
检索PubMed、Embase、Web of Science 和 Cochrane Library，从数据库建立到 2023 年 8 月 16 日收集随机对照试验（RCT）。使用随机效应模型估计标准均数差（SMD）。
结果
共纳入 8 项 RCT，涉及 567 名参与者。荟萃分析显示，姜黄素对焦虑症状有显著影响（SMD：-1.56；95%CI：-2.48，-0.64，p<0.001；I²=95.6%，p 异质性<0.001）。
结论
目前的荟萃分析表明，姜黄素的摄入可能有助于缓解焦虑症。由于纳入的研究数量有限，有必要开展更多高质量的研究来证实姜黄素的临床疗效。
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