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看在上帝的份上：发现一种天然存在的斑马鱼病毒。

For pet's sake: Discovering a naturally occurring zebrafish virus.

机构信息

Institute of Structural and Molecular Biology, Department of Biological Sciences, Birkbeck College, London, United Kingdom.

Department of Infection Biology, London School of Hygiene and Tropical Medicine, London, United Kingdom.

出版信息

PLoS Biol. 2024 Jun 10;22(6):e3002643. doi: 10.1371/journal.pbio.3002643. eCollection 2024 Jun.

DOI:10.1371/journal.pbio.3002643
PMID:38857360
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC11164412/
Abstract

Zebrafish are often used to model host-pathogen interactions, but few models of natural virus infection have been established. A new study in PLOS Biology shows that metatranscriptomics and cohousing experiments can uncover a natural pathogenic virus of zebrafish for laboratory study.

摘要

斑马鱼常用于模拟宿主-病原体相互作用，但很少建立自然病毒感染的模型。PLOS Biology 的一项新研究表明，宏转录组学和共培养实验可以揭示一种用于实验室研究的斑马鱼天然致病性病毒。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/05b5/11164412/6bfaaadac827/pbio.3002643.g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/05b5/11164412/6bfaaadac827/pbio.3002643.g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/05b5/11164412/6bfaaadac827/pbio.3002643.g001.jpg

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本文引用的文献

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Microbe transmission from pet shop to lab-reared zebrafish reveals a pathogenic birnavirus.宠物店到实验室养殖的斑马鱼的微生物传播揭示了一种致病性双 RNA 病毒。
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2
Exploring Zebrafish Larvae as a COVID-19 Model: Probable Abortive SARS-CoV-2 Replication in the Swim Bladder.探索斑马鱼幼鱼作为 COVID-19 模型：在鳔中可能发生 SARS-CoV-2 的流产复制。
Front Cell Infect Microbiol. 2022 Mar 11;12:790851. doi: 10.3389/fcimb.2022.790851. eCollection 2022.
3
Modeling Virus-Induced Inflammation in Zebrafish: A Balance Between Infection Control and Excessive Inflammation.
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Front Immunol. 2021 May 7;12:636623. doi: 10.3389/fimmu.2021.636623. eCollection 2021.
4
Infection of zebrafish larvae with human norovirus and evaluation of the in vivo efficacy of small-molecule inhibitors.用人诺如病毒感染斑马鱼幼虫并评估小分子抑制剂的体内疗效。
Nat Protoc. 2021 Apr;16(4):1830-1849. doi: 10.1038/s41596-021-00499-0. Epub 2021 Apr 9.
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Linking Virus Discovery to Immune Responses Visualized during Zebrafish Infections.将病毒发现与斑马鱼感染过程中的免疫反应联系起来。
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