建立用于研究野生型和重组欧洲六须鲶鱼病毒的斑马鱼感染模型。
Establishment of a Zebrafish Infection Model for the Study of Wild-Type and Recombinant European Sheatfish Virus.
作者信息
Martín Verónica, Mavian Carla, López Bueno Alberto, de Molina Antonio, Díaz Eduardo, Andrés Germán, Alcami Antonio, Alejo Alí
机构信息
Centro de Investigación en Sanidad Animal, Instituto Nacional de Investigación y Tecnología Agraria y Alimentaria, Valdeolmos, Spain.
Centro de Biología Molecular Severo Ochoa (Consejo Superior de Investigaciones Científicas and Universidad Autónoma de Madrid), Madrid, Spain.
出版信息
J Virol. 2015 Oct;89(20):10702-6. doi: 10.1128/JVI.01580-15. Epub 2015 Aug 5.
Abstract
Amphibian-like ranaviruses include pathogens of fish, amphibians, and reptiles that have recently evolved from a fish-infecting ancestor. The molecular determinants of host range and virulence in this group are largely unknown, and currently fish infection models are lacking. We show that European sheatfish virus (ESV) can productively infect zebrafish, causing a lethal pathology, and describe a method for the generation of recombinant ESV, establishing a useful model for the study of fish ranavirus infections.
摘要
类两栖蛙病毒包括鱼类、两栖类和爬行类的病原体，它们最近从一种感染鱼类的祖先进化而来。该类病毒宿主范围和毒力的分子决定因素在很大程度上尚不清楚，目前也缺乏鱼类感染模型。我们发现欧洲六须鲶病毒（ESV）能有效感染斑马鱼，引发致死性病理变化，并描述了一种产生重组ESV的方法，从而建立了一个研究鱼类蛙病毒感染的有用模型。
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