Hays P M, Cruikshank D P, Dunn L J
Am J Obstet Gynecol. 1985 Apr 1;151(7):958-66. doi: 10.1016/0002-9378(85)90675-1.
To determine the clinical usefulness of plasma volume determinations, we measured plasma volume serially throughout pregnancy with the use of the Evans blue dye-dilution technique in 20 subjects with normal pregnancies. In comparison, four preeclamptic subjects were studied. In preeclamptic subjects compared to normal subjects, plasma volume was reduced (1763 +/- 216 versus 2345 +/- 198 ml/m2, p less than 0.001). Two normotensive subjects who subsequently developed preeclampsia had reduced plasma volumes prior to the onset of hypertension as compared to volumes in those who remained normotensive (1918 +/- 86 versus 2345 +/- 198 ml/m2, p less than 0.01). Those subjects who were delivered of infants who were small for gestational age had significantly reduced plasma volumes compared to volumes of those who were delivered of infants who were appropriate for gestational age (1950 +/- 333 versus 2237 +/- 259 ml/m2, p less than 0.05), but this was true only among gravid women with pregnancies complicated by preeclampsia. We conclude that failure of plasma volume expansion is associated with the development of preeclampsia and also intrauterine fetal growth retardation in preeclamptic subjects.
为了确定血浆容量测定的临床实用性，我们使用伊文思蓝染料稀释技术，对20例正常妊娠的受试者在整个孕期进行了连续的血浆容量测量。作为对照，对4例先兆子痫患者进行了研究。与正常受试者相比，先兆子痫患者的血浆容量减少（分别为1763±216与2345±198 ml/m²，p<0.001）。两名血压正常但随后发生先兆子痫的受试者，在高血压发作前的血浆容量低于血压一直正常的受试者（分别为1918±86与2345±198 ml/m²，p<0.01）。与分娩适于胎龄儿的受试者相比，分娩小于胎龄儿的受试者血浆容量显著减少（分别为1950±333与2237±259 ml/m²，p<0.05），但这仅在合并先兆子痫的孕妇中如此。我们得出结论，血浆容量未能增加与先兆子痫的发生以及先兆子痫患者的胎儿宫内生长受限有关。
