阻塞性睡眠呼吸暂停中低密度脂蛋白胆固醇的基因变异与代谢紊乱的关系

Genetic variations of low-density lipoprotein cholesterol on metabolic disorders in obstructive sleep apnea.

作者信息

Peng Yu, Shen Hangdong, Li Chenyang, Zhu Xiaoyue, Gao Yiqing, Yi Hongliang, Xu Huajun, Guan Jian, Li Xinyi, Yin Shankai

机构信息

Department of Otorhinolaryngology Head and Neck Surgery, Shanghai Key Laboratory of Sleep Disordered Breathing, Shanghai Sixth People's Hospital Affiliated to Shanghai Jiao Tong University School of Medicine&, 600 Yishan Road, Shanghai, 200233, P. R. China.

Otolaryngology Institute of Shanghai Jiao Tong University, Shanghai, China.

出版信息

Nutr Metab (Lond). 2024 Jun 10;21(1):31. doi: 10.1186/s12986-024-00805-z.

DOI:10.1186/s12986-024-00805-z

PMID:38858772

原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC11163771/

Abstract

BACKGROUND

The study aimed to explore the relationship between low-density lipoprotein cholesterol (LDL-C) genetic variants and obstructive sleep apnea (OSA) and its complications, including cardiovascular diseases (CVD), insulin resistance (IR), and metabolic syndrome (MS).

METHOD

4329 individuals with suspected OSA who underwent a comprehensive assessment of anthropometric, biochemical, and polysomnography (PSG) data, along with 30 LDL-C single nucleotide polymorphisms (SNPs) were enrolled. The 10-year Framingham CVD risk score (FRS), IR and MS were evaluated for each subject. Linear regression and logistic regression were utilized to examine the correlations among these variables.

RESULTS

After the Benjamini-Hochberg correction, linear regression results indicated positive correlations between variants rs3741297 and rs629301 with FRS (β = 0.031, P=0.002; β = 0.026, P=0.015). Logistic regression revealed that rs3741297 increased MS risk among total subjects [OR = 1.67 (95% CI:1.369-2.038), P=1.32 × 10] and increased IR risk in females [OR = 3.475 (95% CI:1.653-7.307), P=0.03]. In males, rs2642438 decreased MS risk [OR = 0.81 (95% CI:0.703-0.933), P=0.045].

CONCLUSIONS

The rs3741297 variant correlated with susceptibility to CVD, IR, and MS in the OSA population. OSA, CVD, IR and MS share a potentially common genetic background, which may promote precision medicine.

CINICAL TRIAL REGISTRATION

The study protocol was registered with the Chinese Clinical Trial Registry (ChiCTR1900025714).

摘要

背景

本研究旨在探讨低密度脂蛋白胆固醇（LDL-C）基因变异与阻塞性睡眠呼吸暂停（OSA）及其并发症之间的关系，这些并发症包括心血管疾病（CVD）、胰岛素抵抗（IR）和代谢综合征（MS）。

方法

纳入4329例疑似OSA患者，对其进行人体测量学、生化指标及多导睡眠图（PSG）数据的综合评估，并检测30个LDL-C单核苷酸多态性（SNP）。评估每位受试者的10年弗雷明汉心血管疾病风险评分（FRS）、IR及MS情况。采用线性回归和逻辑回归分析这些变量之间的相关性。

结果

经本贾尼-霍奇伯格校正后，线性回归结果显示，rs3741297和rs629301变异与FRS呈正相关（β = 0.031，P = 0.002；β = 0.026，P = 0.015）。逻辑回归显示，rs3741297增加了所有受试者患MS的风险[比值比（OR）= 1.67（95%可信区间：1.369 - 2.038），P = 1.32×10]，并增加了女性患IR的风险[OR = 3.475（95%可信区间：1.653 - 7.307），P = 0.03]。在男性中，rs2642438降低了MS风险[OR = 0.81（95%可信区间：0.703 - 0.933），P = 0.045]。