Opt Express. 2024 Apr 8;32(8):13783-13796. doi: 10.1364/OE.519188.
The conical fiber SPR sensor is easy to manufacture and has been used in biochemical detection research, but it has the problem of structural fragility. This article proposes a spiral cone fiber SPR sensor, which introduces a spiral structure on the 76µm fiber coarse cone, achieving good coupling of the core mode into the cladding mode, and improving the physical strength and practicality of the cone-shaped fiber SPR sensor. By modifying the target protein on the surface of the sensor gold film, specific detection of ginsenoside Rg1, an active ingredient of traditional Chinese medicine ginseng, was achieved. The detection sensitivity was 0.138 nm/(µm/ml) and the detection limit was 0.22µm/ml. The proposed spiral cone fiber SPR sensor provides a new scheme for the specific detection of active ingredients in traditional Chinese medicine, which is structurally stable and physically strong.
锥形纤维 SPR 传感器易于制造，已被用于生化检测研究，但存在结构脆弱的问题。本文提出了一种螺旋锥形光纤 SPR 传感器，在 76μm 光纤粗锥上引入了螺旋结构，实现了芯模到包层模的良好耦合，提高了锥形光纤 SPR 传感器的物理强度和实用性。通过修饰传感器金膜表面的目标蛋白，实现了对中药人参有效成分人参皂苷 Rg1 的特异性检测。检测灵敏度为 0.138nm/(µm/ml)，检测限为 0.22µm/ml。所提出的螺旋锥形光纤 SPR 传感器为中药有效成分的特异性检测提供了一种新的方案，其结构稳定，物理强度高。
