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Exploring the role of underrepresented populations in polygenic risk scores for neurodegenerative disease risk prediction.

作者信息

Step Kathryn, Ndong Sima Carene Anne Alene, Mata Ignacio, Bardien Soraya

机构信息

Division of Molecular Biology and Human Genetics, Faculty of Medicine and Health Sciences, Stellenbosch University, Cape Town, South Africa.

Genomic Medicine, Lerner Research Institute, Cleveland Clinic Foundation, Cleveland, OH, United States.

出版信息

Front Neurosci. 2024 May 27;18:1380860. doi: 10.3389/fnins.2024.1380860. eCollection 2024.

DOI:10.3389/fnins.2024.1380860
PMID:38859922
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC11163124/
Abstract
摘要
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/8b95/11163124/d826d249803d/fnins-18-1380860-g0001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/8b95/11163124/d826d249803d/fnins-18-1380860-g0001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/8b95/11163124/d826d249803d/fnins-18-1380860-g0001.jpg

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Global, regional, and national burden of disorders affecting the nervous system, 1990-2021: a systematic analysis for the Global Burden of Disease Study 2021.全球、区域和国家神经障碍疾病负担，1990-2021 年：2021 年全球疾病负担研究的系统分析。
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Multi-ancestry genome-wide association meta-analysis of Parkinson's disease.
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Nat Genet. 2024 Jan;56(1):27-36. doi: 10.1038/s41588-023-01584-8. Epub 2023 Dec 28.
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A benchmark study on current GWAS models in admixed populations.混合人群中当前 GWAS 模型的基准研究。
Brief Bioinform. 2023 Nov 22;25(1). doi: 10.1093/bib/bbad437.
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Massive underrepresentation of Arabs in genomic studies of common disease.常见疾病的基因组研究中阿拉伯人严重代表性不足。
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