Nichols Noah M, Ezzat Bahie, Waters Allison C, Panov Fedor, Yong Raymund L, Germano Isabelle M
Department of Neurosurgery, Mount Sinai School of Medicine, New York, NY, United States.
School of Medicine, Mount Sinai School of Medicine, New York, NY, United States.
Front Hum Neurosci. 2024 May 27;18:1382380. doi: 10.3389/fnhum.2024.1382380. eCollection 2024.
Cognitive impairment has a profound deleterious impact on long-term outcomes of glioma surgery. The human insula, a deep cortical structure covered by the operculum, plays a role in a wide range of cognitive functions including interceptive thoughts and salience processing. Both low-grade (LGG) and high-grade gliomas (HGG) involve the insula, representing up to 25% of LGG and 10% of HGG. Surgical series from the past 30 years support the role of primary cytoreductive surgery for insular glioma patients; however, reported cognitive outcomes are often limited to speech and language function. The breath of recent neuroscience literature demonstrates that the insula plays a broader role in cognition including interoceptive thoughts and salience processing. This article summarizes the vast functional role of the healthy human insula highlighting how this knowledge can be leveraged to improve the care of patients with insular gliomas.
认知障碍对胶质瘤手术的长期预后有着深远的有害影响。人类岛叶是一个被 operculum 覆盖的深部皮质结构，在包括拦截性思维和显著性加工等广泛的认知功能中发挥作用。低级别（LGG）和高级别胶质瘤（HGG）均累及岛叶，分别占 LGG 的 25%和 HGG 的 10%。过去 30 年的手术系列研究支持了原发性细胞减灭术对岛叶胶质瘤患者的作用；然而，报道的认知结果往往仅限于言语和语言功能。近期神经科学文献表明，岛叶在认知中发挥着更广泛的作用，包括内感受性思维和显著性加工。本文总结了健康人类岛叶的巨大功能作用，强调了如何利用这些知识来改善岛叶胶质瘤患者的护理。
