Laboratory of Chemical Pharmacology, Graduate School of Pharmaceutical Sciences, The University of Tokyo, Tokyo, Japan.
Department of Biophysics and Biochemistry, Graduate School of Science, The University of Tokyo, Tokyo, Japan.
Front Neural Circuits. 2024 May 27;18:1409680. doi: 10.3389/fncir.2024.1409680. eCollection 2024.
The brain constructs spatially organized sensory maps to represent sensory information. The formation of sensory maps has traditionally been thought to depend on synchronous neuronal activity. However, recent evidence from the olfactory system suggests that cell type-specific temporal patterns of spontaneous activity play an instructive role in shaping the olfactory glomerular map. These findings challenge traditional views and highlight the importance of investigating the spatiotemporal dynamics of neural activity to understand the development of complex neural circuits. This review discusses the implications of new findings in the olfactory system and outlines future research directions.
大脑构建空间组织的感觉图谱来表示感觉信息。感觉图谱的形成传统上被认为依赖于同步的神经元活动。然而，来自嗅觉系统的最新证据表明，自发性活动的细胞类型特异性时间模式在塑造嗅觉小球图中起着指导作用。这些发现挑战了传统观点，并强调了研究神经活动的时空动态以理解复杂神经网络发育的重要性。本综述讨论了嗅觉系统中新发现的意义，并概述了未来的研究方向。
