发育中的丘脑和皮层感觉网络中的自发性活动。
Spontaneous activity in developing thalamic and cortical sensory networks.
机构信息
Instituto de Neurociencias de Alicante, Universidad Miguel Hernández-Consejo Superior de Investigaciones Científicas (UMH-CSIC), Sant Joan d'Alacant, Spain.
Instituto de Neurociencias de Alicante, Universidad Miguel Hernández-Consejo Superior de Investigaciones Científicas (UMH-CSIC), Sant Joan d'Alacant, Spain.
出版信息
Neuron. 2021 Aug 18;109(16):2519-2534. doi: 10.1016/j.neuron.2021.06.026. Epub 2021 Jul 21.
Developing sensory circuits exhibit different patterns of spontaneous activity, patterns that are related to the construction and refinement of functional networks. During the development of different sensory modalities, spontaneous activity originates in the immature peripheral sensory structures and in the higher-order central structures, such as the thalamus and cortex. Certainly, the perinatal thalamus exhibits spontaneous calcium waves, a pattern of activity that is fundamental for the formation of sensory maps and for circuit plasticity. Here, we review our current understanding of the maturation of early (including embryonic) patterns of spontaneous activity and their influence on the assembly of thalamic and cortical sensory networks. Overall, the data currently available suggest similarities between the developmental trajectory of brain activity in experimental models and humans, which in the future may help to improve the early diagnosis of developmental disorders.
发育中的感觉回路表现出不同模式的自发性活动，这些模式与功能网络的构建和细化有关。在不同感觉模态的发育过程中，自发性活动源自未成熟的外周感觉结构和更高阶的中枢结构，如丘脑和皮层。当然，围产期丘脑表现出自发性钙波，这是形成感觉图谱和回路可塑性的基本活动模式。在这里，我们回顾了我们目前对早期（包括胚胎期）自发性活动模式的成熟及其对丘脑和皮层感觉网络组装的影响的理解。总的来说，目前可用的数据表明，实验模型和人类大脑活动的发育轨迹之间存在相似性，这可能有助于未来改善发育障碍的早期诊断。
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