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与溃疡性结肠炎相关的分子靶点及白术内酯类疗法的益处。

Molecular targets associated with ulcerative colitis and the benefits of atractylenolides-based therapy.

作者信息

Qian Huanzhu, Ye Zhen, Hu Yu, Wu Mingquan, Chen Liulin, Li Linzhen, Hu Zhipeng, Zhao Qian, Zhang Chen, Yang Maoyi, Xudong Wen, Ye Qiaobo, Qin Kaihua

机构信息

School of Basic Medical Sciences, Chengdu University of Traditional Chinese Medicine, Chengdu, Sichuan, China.

Department of Pharmacy, Sichuan Orthopedic Hospital, Chengdu, Sichuan, China.

出版信息

Front Pharmacol. 2024 May 27;15:1398294. doi: 10.3389/fphar.2024.1398294. eCollection 2024.

DOI:10.3389/fphar.2024.1398294
PMID:38860174
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC11163078/
Abstract

Ulcerative colitis (UC) is a chronic inflammatory disease of the intestines that can significantly impact quality of life and lead to various complications. Currently, 5-aminosalicylic acid derivatives, corticosteroids, immunosuppressants, and biologics are the major treatment strategies for UC, but their limitations have raised concerns. Atractylenolides (ATs), sesquiterpene metabolites found in Koidz., have shown promising effects in treating UC by exerting immune barrier modulation, alleviating oxidative stress, gut microbiota regulation, improving mitochondrial dysfunction and repairing the intestinal barrier. Furthermore, ATs have been shown to possess remarkable anti-fibrosis, anti-thrombus, anti-angiogenesis and anti-cancer. These findings suggest that ATs hold important potential in treating UC and its complications. Therefore, this review systematically summarizes the efficacy and potential mechanisms of ATs in treating UC and its complications, providing the latest insights for further research and clinical applications.

摘要

溃疡性结肠炎（UC）是一种肠道慢性炎症性疾病，会显著影响生活质量并导致各种并发症。目前，5-氨基水杨酸衍生物、皮质类固醇、免疫抑制剂和生物制剂是UC的主要治疗策略，但它们的局限性引发了人们的关注。白术内酯（ATs）是白术中发现的倍半萜代谢产物，通过调节免疫屏障、减轻氧化应激、调节肠道微生物群、改善线粒体功能障碍和修复肠道屏障，在治疗UC方面显示出有前景的效果。此外，ATs已被证明具有显著的抗纤维化、抗血栓、抗血管生成和抗癌作用。这些发现表明，ATs在治疗UC及其并发症方面具有重要潜力。因此，本综述系统总结了ATs在治疗UC及其并发症方面的疗效和潜在机制，为进一步研究和临床应用提供最新见解。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/e6ef/11163078/a6a3e197c515/fphar-15-1398294-g005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/e6ef/11163078/7287eaf149ee/fphar-15-1398294-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/e6ef/11163078/a304d56e62ed/fphar-15-1398294-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/e6ef/11163078/faa93f64f8ab/fphar-15-1398294-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/e6ef/11163078/d21eb1f9779e/fphar-15-1398294-g004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/e6ef/11163078/a6a3e197c515/fphar-15-1398294-g005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/e6ef/11163078/7287eaf149ee/fphar-15-1398294-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/e6ef/11163078/a304d56e62ed/fphar-15-1398294-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/e6ef/11163078/faa93f64f8ab/fphar-15-1398294-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/e6ef/11163078/d21eb1f9779e/fphar-15-1398294-g004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/e6ef/11163078/a6a3e197c515/fphar-15-1398294-g005.jpg

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