Graduate University of Science and Technology, Vietnam Academy of Science and Technology (VAST).
Center for Research and Technology Transfer, VAST.
Chem Pharm Bull (Tokyo). 2023 Jun 1;71(6):451-453. doi: 10.1248/cpb.c22-00779. Epub 2023 Mar 23.
Two new compounds, named eudesm-4(15),7-diene-3α,9β,11-triol (1) and eudesm-4(15),7-diene-1β,3α,9β,11-tetraol (2) together with three known sesquiterpene lactones (1S,5R,7R,10R)-secoatractylolactone (3), (1S,5R,7R,10R)-secoatractylolactone-11-O-β-D-glucopyranoside (4) atractylenolide III (5) were isolated from the rhizomes of Atractylodes macrocephala. Their structures were elucidated by using one-dimensional (1D) and 2D-NMR spectra and high resolution electrospray ionization (HR-ESI)-MS data. Compound 5 exhibited the most active anti-inflammatory activity with IC values of 27.5 µM in inhibiting of nitric oxide production. Compounds 1, 2, and 3 showed moderate effects while compound 4 was inactive.
两种新化合物，命名为桉烷-4(15),7-二烯-3α,9β,11-三醇（1）和桉烷-4(15),7-二烯-1β,3α,9β,11-四醇（2），以及三种已知的倍半萜内酯（1S,5R,7R,10R）-secoatractylolactone（3），（1S,5R,7R,10R）-secoatractylolactone-11-O-β-D-glucopyranoside（4）和阿魏酸 III（5），从白术的根茎中分离得到。它们的结构通过一维（1D）和二维 NMR 光谱和高分辨率电喷雾电离（HR-ESI）-MS 数据来阐明。化合物 5 表现出最强的抗炎活性，在抑制一氧化氮生成方面的 IC 值为 27.5µM。化合物 1、2 和 3 表现出中等效果，而化合物 4 则没有活性。
