Center for Cell Structure and Function, Shandong Provincial Key Laboratory of Animal Resistance Biology, Collaborative Innovation Center of Cell Biology in Universities of Shandong, College of Life Sciences, Shandong Normal University, Jinan, China.
J Cell Physiol. 2024 Aug;239(8):e31325. doi: 10.1002/jcp.31325. Epub 2024 Jun 11.
Precise regulation of stem cell quiescence is essential for tissue development and homeostasis. Therefore, its aberrant regulation is intimately correlated with various human diseases. However, the detailed mechanisms of stem cell quiescence and its specific role in the pathogenesis of various diseases remain to be determined. Recent studies have revealed that the intrinsic and microenvironmental factors are the potential candidates responsible for the orderly switch between the dormant and activated states of stem cells. In addition, defects in signaling pathways related to internal and external factors of stem cells might contribute to the initiation and development of diseases by altering the dormancy of stem cells. In this review, we focus on the mechanisms underlying stem cell quiescence, especially the involvement of intrinsic and microenvironmental factors. In addition, we discuss the relationship between the anomalies of stem cell quiescence and related diseases, hopefully providing therapeutic insights for developing novel treatments.
精确调控干细胞静息状态对于组织发育和稳态至关重要。因此，其异常调控与各种人类疾病密切相关。然而，干细胞静息的详细机制及其在各种疾病发病机制中的具体作用仍有待确定。最近的研究表明，内在和微环境因素是负责干细胞休眠和激活状态有序转换的潜在候选因素。此外，与干细胞内外因素相关的信号通路缺陷可能通过改变干细胞的休眠状态，导致疾病的发生和发展。在这篇综述中，我们重点关注干细胞静息的机制，特别是内在和微环境因素的参与。此外，我们还讨论了干细胞静息异常与相关疾病之间的关系，希望为开发新的治疗方法提供治疗思路。
