Theodorou Stavroula J, Theodorou Daphne J, Kigka Vassiliki, Gkiatas Ioannis, Fotopoulos Andreas
Department of Radiology, University Hospital of Ioannina, Ioannina, Greece.
Department of Radiology, General Hospital of Ioannina and National Healthcare System, Ioannina, Greece.
Rheumatol Int. 2024 Sep;44(9):1715-1723. doi: 10.1007/s00296-024-05622-4. Epub 2024 Jun 11.
As the global population of older persons increases, age-related medical conditions will have a greater impact on public health. DXA-derived bone and soft tissue metrics are associated with adverse clinical events in aging persons. This study aims to investigate the regional body composition of the appendices by whole-body DXA scans, and the age-related relationships between measures of bone and soft tissue in healthy Caucasian females of a Greek origin residing in the Mediterranean area. Body composition of the legs and the arms was analyzed, and lean mass (LM) and fat mass (FM) metrics were calculated in 330 women aged 20-85 years, using DXA. Peak bone mineral density (BMD) of the legs and arms was achieved between ages 20-30 and 41-50 years, respectively. The overall BMD reduction with age was for the legs 43% and the arms 32.2% (p < 0.001). Peak %LM of the legs and the arms was achieved between ages 20-30. The overall reduction of %LM with age was for the legs 22.5% (p < 0.001) and arms 6.6% (p < 0.05). Peak %FM of the legs and arms was attained between ages 31-40 and 61-70, respectively. The overall %FM reduction with age was for the legs and arms 7.5% and 1.9% (p > 0.05). In appendicular sites, Greek women reach peak values of bone mass in the legs first, in early adulthood. Bone loss predominates in the legs as women age. Also, with advancing age Greek women show preferential significant decreases of %LM and %FM in the legs as opposed to the arms. Although variation in appendicular bone and soft tissue metrics is present, the implications of variable biological crosstalks among the tissue components as women age may ultimately lay the foundation for future clinical trials aimed at healthy aging.
随着全球老年人口的增加，与年龄相关的医疗状况将对公共卫生产生更大影响。双能X线吸收法（DXA）得出的骨骼和软组织指标与老年人的不良临床事件相关。本研究旨在通过全身DXA扫描调查四肢的区域身体成分，以及居住在地中海地区的希腊裔健康白种女性中骨骼和软组织测量值与年龄的关系。使用DXA分析了腿部和手臂的身体成分，并计算了330名年龄在20至85岁女性的瘦体重（LM）和脂肪量（FM）指标。腿部和手臂的骨密度峰值分别在20至30岁和41至50岁之间达到。随着年龄增长，腿部的总体骨密度降低了43%，手臂降低了32.2%（p<0.001）。腿部和手臂的瘦体重百分比（%LM）峰值在20至30岁之间达到。随着年龄增长，腿部的%LM总体降低了22.5%（p<0.001），手臂降低了6.6%（p<0.05）。腿部和手臂的脂肪量百分比（%FM）峰值分别在31至40岁和61至70岁之间达到。随着年龄增长，腿部和手臂的%FM总体降低分别为7.5%和1.9%（p>0.05）。在四肢部位，希腊女性在成年早期首先在腿部达到骨量峰值。随着女性年龄增长，腿部骨质流失占主导。此外，随着年龄增长，希腊女性腿部的%LM和%FM相较于手臂呈现出更显著的优先下降。尽管四肢骨骼和软组织指标存在差异，但随着女性年龄增长，组织成分之间可变的生物学相互作用的影响可能最终为旨在实现健康老龄化的未来临床试验奠定基础。
