Hou Song-Yu, Yan Bing-Chao, Sun Han-Dong, Puno Pema-Tenzin
Key Laboratory of Phytochemistry and Natural Medicines, Kunming Institute of Botany, University of Chinese Academy of Sciences, Chinese Academy of Sciences, Kunming, 650201, Yunnan, People's Republic of China.
Nat Prod Bioprospect. 2024 Jun 11;14(1):37. doi: 10.1007/s13659-024-00457-9.
Cyclobutanes are distributed widely in a large class of natural products featuring diverse pharmaceutical activities and intricate structural frameworks. The [2 + 2] cycloaddition is unequivocally the primary and most commonly used method for synthesizing cyclobutanes. In this review, we have summarized the application of the [2 + 2] cycloaddition with different reaction mechanisms in the chemical synthesis of selected cyclobutane-containing natural products over the past decade.
环丁烷广泛分布于一大类具有多种药物活性和复杂结构框架的天然产物中。[2 + 2]环加成反应无疑是合成环丁烷的主要且最常用的方法。在本综述中，我们总结了过去十年中具有不同反应机理的[2 + 2]环加成反应在选定的含环丁烷天然产物化学合成中的应用。
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