Department of Biomedical Engineering, Yildiz Technical University, Esenler, Istanbul 34220, Turkey.
Department of Biomedical Engineering, Yildiz Technical University, Esenler, Istanbul 34220, Turkey.
Comput Biol Med. 2024 Aug;178:108698. doi: 10.1016/j.compbiomed.2024.108698. Epub 2024 Jun 4.
The auscultation is a non-invasive and cost-effective method used for the diagnosis of lung diseases, which are one of the leading causes of death worldwide. However, the efficacy of the auscultation suffers from the limitations of the analog stethoscopes and the subjective nature of human interpretation. To overcome these limitations, the accurate diagnosis of these diseases by employing the computer based automated algorithms applied to the digitized lung sounds has been studied for the last decades. This study proposes a novel approach that uses a Tunable Q-factor Wavelet Transform (TQWT) based statistical feature extraction followed by individual and ensemble learning model training with the aim of lung disease classification. During the learning stage various machine learning algorithms are utilized as the individual learners as well as the hard and soft voting fusion approaches are employed for performance enhancement with the aid of the predictions of individual models. For an objective evaluation of the proposed approach, the study was structured into two main tasks that were investigated in detail by using several sub-tasks to comparison with state-of-the-art studies. Among the sub-tasks which investigates patient-based classification, the highest accuracy obtained for the binary classification was achieved as 97.63% (healthy vs. non-healthy), while accuracy values up to 66.32% for three-class classification (obstructive-related, restrictive-related, and healthy), and 53.42% for five-class classification (asthma, chronic obstructive pulmonary disease, interstitial lung disease, pulmonary infection, and healthy) were obtained. Regarding the other sub-task, which investigates sample-based classification, the proposed approach was superior to almost all previous findings. The proposed method underscores the potential of TQWT based signal decomposition that leverages the power of its adaptive time-frequency resolution property satisfied by Q-factor adjustability. The obtained results are very promising and the proposed approach paves the way for more accurate and automated digital auscultation techniques in clinical settings.
听诊是一种非侵入性且具有成本效益的方法,用于诊断肺部疾病,肺部疾病是全球主要死因之一。然而,听诊的效果受到模拟听诊器的限制和人类解释的主观性的限制。为了克服这些限制,过去几十年来一直研究通过将基于计算机的自动算法应用于数字化的肺部声音来准确诊断这些疾病。本研究提出了一种新方法,该方法使用基于可调 Q 因子小波变换(TQWT)的统计特征提取,然后对个体和集成学习模型进行训练,旨在进行肺部疾病分类。在学习阶段,使用各种机器学习算法作为个体学习者,并且使用硬投票和软投票融合方法来提高性能,同时借助个体模型的预测来增强性能。为了对所提出的方法进行客观评估,该研究分为两个主要任务,通过使用多个子任务进行详细研究,与最先进的研究进行比较。在子任务中,其中一个是基于患者的分类,二进制分类的最高精度达到了 97.63%(健康与非健康),而对于三分类(阻塞性相关、限制性相关和健康)的分类精度达到了 66.32%,对于五分类(哮喘、慢性阻塞性肺疾病、间质性肺疾病、肺部感染和健康)的分类精度达到了 53.42%。另一个子任务是基于样本的分类,所提出的方法优于几乎所有以前的发现。该方法强调了基于 TQWT 的信号分解的潜力,该方法利用了 Q 因子可调性满足的自适应时频分辨率特性的优势。所得到的结果非常有前途,所提出的方法为临床环境中更准确和自动化的数字听诊技术铺平了道路。