数字健康指导对急性髓系白血病和慢性淋巴细胞白血病患者自我效能及患者报告结局的影响：一项随机对照试验试点研究
Effect of Digital Health Coaching on Self-Efficacy and Patient-Reported Outcomes in Individuals with Acute Myeloid and Chronic Lymphocytic Leukemia: A Pilot Randomized Controlled Trial.
作者信息
Marvin-Peek Jennifer, Shelton Valerie, Brassil Kelly, Fellman Bryan, Barr Austin, Chien Kelly Sharon, Hammond Danielle, Swaminathan Mahesh, Jain Nitin, Wierda William, Ferrajoli Alessandra, DiNardo Courtney
机构信息
Division of Cancer Medicine, The University of Texas MD Anderson Cancer Center, Houston, Texas, USA,
Department of Nursing, The University of Texas MD Anderson Cancer Center, Houston, Texas, USA.
出版信息
Acta Haematol. 2025;148(2):233-243. doi: 10.1159/000539756. Epub 2024 Jun 11.
INTRODUCTION
Promotion of self-efficacy can enhance engagement with health care and treatment adherence in patients with cancer. We report the outcomes of a pilot trial of a digital health coach intervention in patients with leukemia with the aim of improving self-efficacy.
METHODS
Adult patients with newly diagnosed acute myeloid leukemia (AML) and chronic lymphocytic leukemia (CLL) were randomized 1:1 to a digital health coach intervention or standard of care. The primary outcome of self-efficacy was measured by the Cancer Behavior Inventory (CBI) score.
RESULTS
A total of 147 patients (37 AML, 110 CLL) were enrolled from July 2020 to December 2022. In the AML cohort, there was a mean increase in CBI score of 7.03 in the digital health coaching arm compared to a mean decrease of -3.57 in the control arm at 30 days (p = 0.219). There were no significant associations between the intervention and other patient-reported outcomes for patients with CLL.
CONCLUSION
There were numerical, but not statistically significant increases in self-efficacy metrics in AML patients who received digital health coaching. Although this trial was underpowered due to enrollment limitations during a pandemic, digital health coaching may provide benefit to patients with hematologic malignancy and warrants further investigation.
INTRODUCTION
Promotion of self-efficacy can enhance engagement with health care and treatment adherence in patients with cancer. We report the outcomes of a pilot trial of a digital health coach intervention in patients with leukemia with the aim of improving self-efficacy.
METHODS
Adult patients with newly diagnosed acute myeloid leukemia (AML) and chronic lymphocytic leukemia (CLL) were randomized 1:1 to a digital health coach intervention or standard of care. The primary outcome of self-efficacy was measured by the Cancer Behavior Inventory (CBI) score.
RESULTS
A total of 147 patients (37 AML, 110 CLL) were enrolled from July 2020 to December 2022. In the AML cohort, there was a mean increase in CBI score of 7.03 in the digital health coaching arm compared to a mean decrease of -3.57 in the control arm at 30 days (p = 0.219). There were no significant associations between the intervention and other patient-reported outcomes for patients with CLL.
CONCLUSION
There were numerical, but not statistically significant increases in self-efficacy metrics in AML patients who received digital health coaching. Although this trial was underpowered due to enrollment limitations during a pandemic, digital health coaching may provide benefit to patients with hematologic malignancy and warrants further investigation.
引言
提高自我效能感可增强癌症患者对医疗保健的参与度和治疗依从性。我们报告了一项针对白血病患者的数字健康教练干预试点试验的结果，旨在提高自我效能感。
方法
将新诊断的急性髓系白血病（AML）和慢性淋巴细胞白血病（CLL）成年患者按1:1随机分为数字健康教练干预组或标准治疗组。自我效能感的主要结局通过癌症行为量表（CBI）评分来衡量。
结果
2020年7月至2022年12月共招募了147例患者（37例AML，110例CLL）。在AML队列中，数字健康教练干预组在30天时CBI评分平均增加7.03，而对照组平均下降-3.57（p = 0.219）。对于CLL患者，干预与其他患者报告的结局之间无显著关联。
结论
接受数字健康教练干预的AML患者的自我效能感指标有数值上的增加，但无统计学意义。尽管由于大流行期间的入组限制，该试验的效能不足，但数字健康教练干预可能对血液系统恶性肿瘤患者有益，值得进一步研究。
引言
提高自我效能感可增强癌症患者对医疗保健的参与度和治疗依从性。我们报告了一项针对白血病患者的数字健康教练干预试点试验的结果，旨在提高自我效能感。
方法
将新诊断的急性髓系白血病（AML）和慢性淋巴细胞白血病（CLL）成年患者按1:1随机分为数字健康教练干预组或标准治疗组。自我效能感的主要结局通过癌症行为量表（CBI）评分来衡量。
结果
2020年7月至2022年12月共招募了147例患者（37例AML，110例CLL）。在AML队列中，数字健康教练干预组在30天时CBI评分平均增加7.03，而对照组平均下降-3.57（p = 0.219）。对于CLL患者，干预与其他患者报告的结局之间无显著关联。
结论
接受数字健康教练干预的AML患者的自我效能感指标有数值上的增加，但无统计学意义。尽管由于大流行期间的入组限制，该试验的效能不足，但数字健康教练干预可能对血液系统恶性肿瘤患者有益，值得进一步研究。
Zotero 插件