College of Science and Health Professions, King Saud bin Abdulaziz University for Health Sciences, Jeddah, Saudi Arabia.
King Abdullah International Medical Research Center, Jeddah, Saudi Arabia.
Lipids Health Dis. 2024 Jun 11;23(1):179. doi: 10.1186/s12944-024-02176-z.
Dry eye disease (DED) is a complication of dyslipidemia (DLP) that is caused by metabolic syndrome and increased inflammation. This research aimed to assess leukocyte and systemic inflammation index ratios as potential biomarkers for systemic inflammation in dyslipidemia patients with dry eye disease (DLP-DED).
Several blood biomarkers were studied in 32 patients with DLP-DED (study group) and 63 patients with DLP-only (control group). The evaluated blood biomarkers included specific systemic inflammation index ratios, such as the neutrophil-to-lymphocyte ratio (NLR), platelet-to-lymphocyte ratio (PLR), monocyte-to-lymphocyte ratio (MLR), and neutrophil-to-lymphocyte and platelet ratio (NLPR), and lipid profiles, such as total cholesterol (TC), high-density lipoprotein cholesterol (HDL), low-density lipoprotein cholesterol (LDL), triglyceride (TG), albumin (ALB), and C-reactive protein (CRP) levels.
Lymphocyte levels were significantly greater in the DLP-DED group than in the DLP-only group (P = 0.044). In addition, a significant negative correlation between HDL and the NLPR (P = 0.007; r= -0.428) and a significant negative correlation between the serum ALB concentration and the PLR (P = 0.008; r= -0.420) were identified as potential inflammatory predictors of DLP-DED.
The findings of this study suggest that patients with DLP-DED may benefit from routine blood monitoring of their elevated lipid profile and blood inflammatory biomarkers, such as CRP, leukocytes, and systemic inflammation index ratios (NLR, PLR, MLR, and NLPR), to reduce the complications of DLP on ocular health. The correlation data suggest that the NLPR, PLR, serum ALB concentration, and serum HDL concentration may be valuable inflammatory biomarkers in DLP-DED patients. More research is required to ascertain the significance of the NLR, PLR, MLR, and NLPR and the additive role that leukocytes play.
干眼症（DED）是由代谢综合征和炎症增加引起的血脂异常（DLP）的并发症。本研究旨在评估白细胞和全身炎症指数比值作为血脂异常伴干眼症（DLP-DED）患者全身炎症的潜在生物标志物。
在 32 例 DLP-DED 患者（研究组）和 63 例仅 DLP 患者（对照组）中研究了几种血液生物标志物。评估的血液生物标志物包括特定的全身炎症指数比值，如中性粒细胞与淋巴细胞比值（NLR）、血小板与淋巴细胞比值（PLR）、单核细胞与淋巴细胞比值（MLR）和中性粒细胞与淋巴细胞和血小板比值（NLPR），以及血脂谱，如总胆固醇（TC）、高密度脂蛋白胆固醇（HDL）、低密度脂蛋白胆固醇（LDL）、甘油三酯（TG）、白蛋白（ALB）和 C 反应蛋白（CRP）水平。
DLP-DED 组淋巴细胞水平明显高于 DLP 组（P=0.044）。此外，还发现 HDL 与 NLPR 呈显著负相关（P=0.007；r=-0.428），血清 ALB 浓度与 PLR 呈显著负相关（P=0.008；r=-0.420），这可能是 DLP-DED 的潜在炎症预测因子。
本研究结果表明，DLP-DED 患者可能受益于常规监测其升高的血脂谱和血液炎症生物标志物，如 CRP、白细胞和全身炎症指数比值（NLR、PLR、MLR 和 NLPR），以降低 DLP 对眼部健康的并发症。相关数据表明，NLPR、PLR、血清 ALB 浓度和血清 HDL 浓度可能是 DLP-DED 患者有价值的炎症生物标志物。需要进一步研究以确定 NLR、PLR、MLR 和 NLPR 的意义以及白细胞的附加作用。
