干眼症与血脂异常的关系：一项系统综述。
Relationship between Dry Eye Disease and Dyslipidemia: A Systematic Review.
作者信息
Wang Tzu-Hao, Tsai Yuan-Jen, Wang Yuan-Hung, Wu Chien-Liang, Lin I-Chan
机构信息
Division of General Medicine, Department of Medical Education, Shuang Ho Hospital, New Taipei City 23561, Taiwan.
Graduate Institute of Biomedical Informatics, College of Medical Science and Technology, Taipei Medical University, Taipei City 11031, Taiwan.
出版信息
J Clin Med. 2023 Oct 20;12(20):6631. doi: 10.3390/jcm12206631.
BACKGROUND
Dyslipidemia has been suggested to be associated with the occurrence of dry eye disease (DED). However, whether dyslipidemia is responsible for the development of DED remains unclear. In this systematic review, we explored the relationship between DED and dyslipidemia by using quantitative data.
METHODS
Following the Preferred Reporting Items for Systematic Reviews and Meta-Analyses guidelines, we conducted a comprehensive literature search in several databases, including PubMed, Embase, Cochrane Library, Web of Science, and Google Scholar, and obtained six relevant studies.
RESULTS
Our findings indicated that the majority of the selected studies reported a statistically significant association between dyslipidemia and DED, particularly in women. However, our quantitative analysis revealed that only two studies reported statistically significant differences in total cholesterol and high-density lipoprotein cholesterol values.
CONCLUSION
No statistically significant differences exist in the majority of lipid profile parameters between individuals with and without DED, but there is a statistically significant association between dyslipidemia and DED.
背景
血脂异常被认为与干眼症（DED）的发生有关。然而，血脂异常是否是导致干眼症的原因仍不清楚。在本系统评价中，我们通过定量数据探讨了干眼症与血脂异常之间的关系。
方法
按照系统评价和Meta分析的首选报告项目指南，我们在多个数据库中进行了全面的文献检索，包括PubMed、Embase、Cochrane图书馆、科学网和谷歌学术，并获得了六项相关研究。
结果
我们的研究结果表明，大多数所选研究报告血脂异常与干眼症之间存在统计学上的显著关联，尤其是在女性中。然而，我们的定量分析显示，只有两项研究报告了总胆固醇和高密度脂蛋白胆固醇值的统计学显著差异。
结论
干眼症患者和非干眼症患者在大多数血脂参数上没有统计学上的显著差异，但血脂异常与干眼症之间存在统计学上的显著关联。
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