Hokama H, Shenton M E, Nestor P G, Kikinis R, Levitt J J, Metcalf D, Wible C G, O'Donnell B F, Jolesz F A, McCarley R W
Harvard Medical School Department of Psychiatry, Brockton/West Roxbury Veterans Affairs Medical Center, Boston, MA, USA.
Psychiatry Res. 1995 Nov 10;61(4):209-29. doi: 10.1016/0925-4927(95)02729-h.
Basal ganglia structures have been reported to be abnormal in schizophrenia. However, while component structures of the basal ganglia are functionally differentiated, there have been no evaluations of their separate magnetic resonance imaging (MRI) volumes with small voxel (1.5 mm3) spoiled gradient-recalled acquisition in steady state techniques and multi-plane assessments. We examined MRI scans from 15 male, right-handed, neuroleptic-medicated schizophrenic patients and 15 age-, handedness-, and gender-matched normal volunteers. Compared with normal subjects, schizophrenic patients showed enlarged volumes: 14.2% for total basal ganglia, 27.4% for globus pallidus, 15.9% for putamen, and 9.5% for caudate. Increased volumes, especially of the caudate, were associated with poorer neuropsychological test performance on finger tapping and Hebb's Recurring Digits. These findings indicate abnormalities throughout all basal ganglia structures in at least a subgroup of schizophrenic patients.
据报道，精神分裂症患者的基底神经节结构存在异常。然而，尽管基底神经节的组成结构在功能上有所分化，但尚未使用小体素（1.5立方毫米）稳态毁损梯度回波采集技术和多平面评估对其单独的磁共振成像（MRI）体积进行评估。我们检查了15名男性、右利手、接受抗精神病药物治疗的精神分裂症患者以及15名年龄、利手和性别匹配的正常志愿者的MRI扫描结果。与正常受试者相比，精神分裂症患者的体积增大：基底神经节总体积增大14.2%，苍白球增大27.4%，壳核增大15.9%，尾状核增大9.5%。体积增加，尤其是尾状核体积增加，与手指轻敲和赫布重复数字等神经心理学测试表现较差有关。这些发现表明，至少在一部分精神分裂症患者中，所有基底神经节结构都存在异常。
