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姜黄：从香料到治愈良药。姜黄源化合物的抗癌、辐射防护及抗炎作用综述。

Turmeric: from spice to cure. A review of the anti-cancer, radioprotective and anti-inflammatory effects of turmeric sourced compounds.

作者信息

Cozmin Mihai, Lungu Ionut Iulian, Gutu Cristian, Stefanache Alina, Duceac Letitia Doina, Șoltuzu Bogdan Dorin, Damir Daniela, Calin Gabriela, Bogdan Goroftei Elena Roxana, Grierosu Carmen, Boev Monica

机构信息

"Apollonia" University of Iasi, Faculty of Dental Medicine, Iași, Romania.

"Grigore T. Popa" University of Medicine and Pharmacy, Iași, Romania.

出版信息

Front Nutr. 2024 May 28;11:1399888. doi: 10.3389/fnut.2024.1399888. eCollection 2024.

DOI:10.3389/fnut.2024.1399888
PMID:38863589
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC11165187/
Abstract

Turmeric () has been extensively studied for its diverse pharmacological properties, including its potential role as an anticancer agent, antioxidant, and radioprotector. This review provides an overview of the chemical composition of turmeric, focusing on its main bioactive compounds, such as curcuminoids and volatile oils. Curcumin, the most abundant curcuminoid in turmeric, has been widely investigated for its various biological activities, including anti-inflammatory, antioxidant, and anticancer effects. Numerous and studies have demonstrated the ability of curcumin to modulate multiple signaling pathways involved in carcinogenesis, leading to inhibition of cancer cell proliferation, induction of apoptosis, and suppression of metastasis. Furthermore, curcumin has shown promising potential as a radioprotective agent by mitigating radiation-induced oxidative stress and DNA damage. Additionally, turmeric extracts containing curcuminoids have been reported to exhibit potent antioxidant activity, scavenging free radicals and protecting cells from oxidative damage. The multifaceted pharmacological properties of turmeric make it a promising candidate for the development of novel therapeutic strategies for cancer prevention and treatment, as well as for the management of oxidative stress-related disorders. However, further research is warranted to elucidate the underlying mechanisms of action and to evaluate the clinical efficacy and safety of turmeric and its bioactive constituents in cancer therapy and radioprotection. This review consolidates the most recent relevant data on turmeric's chemical composition and its therapeutic applications, providing a comprehensive overview of its potential in cancer prevention and treatment, as well as in radioprotection.

摘要

姜黄（）因其多样的药理特性而受到广泛研究，包括其作为抗癌剂、抗氧化剂和辐射防护剂的潜在作用。本综述概述了姜黄的化学成分，重点关注其主要生物活性化合物，如姜黄素类和挥发油。姜黄素是姜黄中含量最丰富的姜黄素类化合物，因其多种生物活性，包括抗炎、抗氧化和抗癌作用而受到广泛研究。大量的 和 研究表明，姜黄素能够调节参与致癌过程的多种信号通路，从而抑制癌细胞增殖、诱导细胞凋亡并抑制转移。此外，姜黄素通过减轻辐射诱导的氧化应激和DNA损伤，显示出作为辐射防护剂的潜在前景。此外，据报道，含有姜黄素类化合物的姜黄提取物具有强大的抗氧化活性，能够清除自由基并保护细胞免受氧化损伤。姜黄的多方面药理特性使其成为开发癌症预防和治疗新策略以及管理氧化应激相关疾病的有前途的候选物。然而，有必要进一步研究以阐明其潜在的作用机制，并评估姜黄及其生物活性成分在癌症治疗和辐射防护中的临床疗效和安全性。本综述整合了关于姜黄化学成分及其治疗应用的最新相关数据，全面概述了其在癌症预防和治疗以及辐射防护方面的潜力。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/d2f2/11165187/1625abdbf25d/fnut-11-1399888-g009.jpg
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