Fuloria Shivkanya, Mehta Jyoti, Chandel Aditi, Sekar Mahendran, Rani Nur Najihah Izzati Mat, Begum M Yasmin, Subramaniyan Vetriselvan, Chidambaram Kumarappan, Thangavelu Lakshmi, Nordin Rusli, Wu Yuan Seng, Sathasivam Kathiresan V, Lum Pei Teng, Meenakshi Dhanalekshmi Unnikrishnan, Kumarasamy Vinoth, Azad Abul Kalam, Fuloria Neeraj Kumar
Faculty of Pharmacy, AIMST University, Kedah, Malaysia.
Faculty of Applied Sciences and Biotechnology, Shoolini University of Biotechnology and Management Sciences, Solan, India.
Front Pharmacol. 2022 Mar 25;13:820806. doi: 10.3389/fphar.2022.820806. eCollection 2022.
Linn. (), popularly known as turmeric, belongs to the Zingiberaceae family and has a long historical background of having healing properties against many diseases. In Unani and Ayurveda medicine, has been used for liver obstruction and jaundice, and has been applied externally for ulcers and inflammation. Additionally, it is employed in several other ailments such as cough, cold, dental issues, indigestion, skin infections, blood purification, asthma, piles, bronchitis, tumor, wounds, and hepatic disorders, and is used as an antiseptic. Curcumin, a major constituent of , is well known for its therapeutic potential in numerous disorders. However, there is a lack of literature on the therapeutic potential of in contrast to curcumin. Hence, the present review aimed to provide in-depth information by highlighting knowledge gaps in traditional and scientific evidence about in relation to curcumin. The relationship to one another in terms of biological action includes their antioxidant, anti-inflammatory, neuroprotective, anticancer, hepatoprotective, cardioprotective, immunomodulatory, antifertility, antimicrobial, antiallergic, antidermatophytic, and antidepressant properties. Furthermore, in-depth discussion of on its taxonomic categorization, traditional uses, botanical description, phytochemical ingredients, pharmacology, toxicity, and safety aspects in relation to its major compound curcumin is needed to explore the trends and perspectives for future research. Considering all of the promising evidence to date, there is still a lack of supportive evidence especially from clinical trials on the adjunct use of and curcumin. This prompts further preclinical and clinical investigations on curcumin.
林奈（），俗称姜黄，属于姜科，具有悠久的历史背景，对多种疾病具有治疗作用。在尤纳尼医学和阿育吠陀医学中，它被用于治疗肝脏梗阻和黄疸，还被外用治疗溃疡和炎症。此外，它还用于治疗其他多种疾病，如咳嗽、感冒、牙齿问题、消化不良、皮肤感染、血液净化、哮喘、痔疮、支气管炎、肿瘤、伤口和肝脏疾病，并用作防腐剂。姜黄素是它的主要成分，以其在众多疾病中的治疗潜力而闻名。然而，与姜黄素相比，关于它的治疗潜力的文献较少。因此，本综述旨在通过突出关于它与姜黄素在传统和科学证据方面的知识空白，提供深入信息。它们在生物学作用方面的相互关系包括抗氧化、抗炎、神经保护、抗癌、肝脏保护、心脏保护、免疫调节、抗生育、抗菌、抗过敏、抗皮肤真菌和抗抑郁特性。此外，需要深入讨论它在分类学分类、传统用途、植物学描述、植物化学成分、药理学、毒性以及与主要化合物姜黄素相关的安全方面，以探索未来研究的趋势和前景。考虑到迄今为止所有有前景的证据，仍然缺乏支持性证据，特别是来自关于它和姜黄素联合使用的临床试验的证据。这促使对姜黄素进行进一步的临床前和临床研究。
