Obstetrics and Gynecology Center, First Hospital of Jilin University, Changchun, Jilin, China.
Department of Rehabilitation, School of Nursing, Jilin University, Changchun, China.
Front Immunol. 2024 May 28;15:1402862. doi: 10.3389/fimmu.2024.1402862. eCollection 2024.
Ovarian cancer, ranking as the seventh most prevalent malignancy among women globally, faces significant challenges in diagnosis and therapeutic intervention. The difficulties in early detection are amplified by the limitations and inefficacies inherent in current screening methodologies, highlighting a pressing need for more efficacious diagnostic and treatment strategies. Phage display technology emerges as a pivotal innovation in this context, utilizing extensive phage-peptide libraries to identify ligands with specificity for cancer cell markers, thus enabling precision-targeted therapeutic strategies. This technology promises a paradigm shift in ovarian cancer management, concentrating on targeted drug delivery systems to improve treatment accuracy and efficacy while minimizing adverse effects. Through a meticulous review, this paper evaluates the revolutionary potential of phage display in enhancing ovarian cancer therapy, representing a significant advancement in combating this challenging disease. Phage display technology is heralded as an essential instrument for developing effective immunodiagnostic and therapeutic approaches in ovarian cancer, facilitating early detection, precision-targeted medication, and the implementation of customized treatment plans.
卵巢癌是全球女性中排名第七的常见恶性肿瘤,在诊断和治疗干预方面面临重大挑战。目前的筛查方法存在局限性和低效性,进一步加剧了早期检测的困难,这凸显了更有效诊断和治疗策略的迫切需求。噬菌体展示技术在此背景下成为一项关键创新,利用广泛的噬菌体-肽库来识别具有癌细胞标志物特异性的配体,从而实现精确靶向的治疗策略。这项技术有望在卵巢癌管理方面带来范式转变,专注于靶向药物输送系统,以提高治疗准确性和疗效,同时最大限度地减少不良反应。通过细致的回顾,本文评估了噬菌体展示在增强卵巢癌治疗方面的革命性潜力,这是对抗这一具有挑战性疾病的重大进展。噬菌体展示技术被视为开发卵巢癌有效免疫诊断和治疗方法的重要工具,有助于早期检测、精确靶向药物治疗以及实施个性化治疗方案。